Results 71 to 80 of about 1,560,476 (306)

Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data

Translational Psychiatry
The heterogeneity of Major Depressive Disorder (MDD) has been increasingly recognized, challenging traditional symptom-based diagnostics and the development of mechanism-targeted therapies.
Lili Tang, Rui Tang, Junjie Zheng, Pengfei Zhao, Rongxin Zhu, Yanqing Tang, Xizhe Zhang, Xiaohong Gong, Fei Wang   +8 more
doaj   +1 more source

Borderline personality disorder in young people: associations with support and negative interactions in relationships with mothers and a best friend

Borderline Personality Disorder and Emotion Dysregulation, 2022
Background Impaired interpersonal functioning has been highlighted as a core feature of borderline personality disorder (BPD). Adolescence and young adulthood form important developmental stages within both the emergence of BPD and the development of ...
Christel J. Hessels, Tessa van den Berg, Sofie A. Lucassen, Odilia M. Laceulle, Marcel A. G. van Aken   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Early Communication Intervention with Young Children with Pierre Robin Sequence

South African Journal of Communication Disorders, 1998
Young children with Pierre Robin sequence are at considerable risk to develop delayed or disordered communication development. This study investigated the effectiveness of early communication intervention with four young children with Pierre Robin ...
Lisl Fair, Brenda Louw
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ENRICHING THE QUALITY AND QUANTITY OF STIMULATION AND SUPPORT AVAILBLE TO A CHILD IN THE HOME ENVIROMENT THROUGHT THE USE OF STANDARDIZED TOOLS IN EARLY INTERVENTION

Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2017
This article describes the use of Home Observation for Measurement of the Environment (HOME) in early inter­ven­tion in a research project inRepublicofMoldova.
Sergiu TOMA, Ivan PUIU
doaj  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Implementation of the NDIS in the early childhood intervention sector in NSW: Report 1

, 2017
Early Childhood Intervention Australia (ECIA) NSW/ACT commissioned the Social Policy Research Centre to conduct research into the experiences of families and ECI service providers in the transition to the NDIS in New South Wales (NSW).
Fisher, KR ; https://orcid.org/, Meltzer, A ; https://orcid.org/, Purcal, C ; https://orcid.org/, Hill, T ; https://orcid.org/   +3 more
core   +1 more source

Early Hearing Detection and Intervention Program [PDF]

Source: 2017 CDC Hearing Screening and Follow-up Survey (HSFS)Percentage of Children Screened, Diagnosed, and Enrolled in Early Intervention in 2017: by Gender2017-HSFS_Screening-Demographic-Summary ...

core   +3 more sources

Effects of cognitive training and behavior modification on aggressive behavior and sleep quality in schizophrenia

Frontiers in Psychiatry
BackgroundSchizophrenia (SCZ) is linked to a heightened risk of impulsive aggression and disturbances in sleep patterns. Cognitive and social cognitive impairments have been connected to aggression, with social cognitive deficits appearing to play a more
Jing Wang, Gangming Cheng, Hongjie Li, Wei Yang   +3 more
doaj   +1 more source