Results 101 to 110 of about 19,801,094 (386)
Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures
JAMA psychiatry, 2019 Key Points Question Are maternal polygenic risk scores for neurodevelopmental disorders associated with early-life exposures? Findings In this population-based cohort study of 7921 mothers, polygenic risk score for attention-deficit/hyperactivity ...
Beate Leppert +9 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
BiologyIn most cases, sponge fossils are preserved as isolated spicules, with complete sponge body fossils largely confined to Konservat-Lagerstätten. Although the classification and diversity of sponges and their isolated spicules have been extensively studied,
Xinyi Ren +5 more
doaj +1 more source
Frontiers in Physiology, 2019 Aim: To investigate whether housing temperature influences rat adiposity, and the extent it is modified by diet and/or pregnancy. Housing temperature impacts on brown adipose tissue, that possess a unique uncoupling protein (UCP) 1, which, when activated
Layla Albustanji +12 more
doaj +1 more source
Order of acquisition in learning perceptual categories: a laboratory analogue of the age-of-acquisition effect? [PDF]
, 2008 In the age-of-acquisition (AoA) effect, an advantage for recognition and production is found for items learned early in life, as compared with items learned later.
Ellis, Andrew W., Stewart, Neil
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Early childhood and the life course [PDF]
What happens to children in the early years has consequences right through the course of their lives. There are many opportunities to intervene and make a difference to the lives of children and young people.
Centre for Community Child Health
core
From traumatic childhood to cocaine abuse: the critical function of the immune system [PDF]
, 2018 Background: Experiencing traumatic childhood is a risk factor for developing substance use disorder (SUD), but the mechanisms that underlie this relationship have not been determined.
Aricò, Eleonora +17 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
eLifeAlthough fossil evidence suggests the existence of an early muscular system in the ancient cnidarian jellyfish from the early Cambrian Kuanchuanpu biota (ca.
Yiheng Zhang +13 more
doaj +1 more source