Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions [PDF]
, 2022 Kitty Reemst +13 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The age separating early deaths from late deaths [PDF]
There is a unique threshold age separating early deaths from late deaths such that averting an early death decreases life disparity, but averting a late death increases inequality in lifespans.life disparity ...
James W. Vaupel, Zhen Zhang
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex [PDF]
, 2021 Xiuping Sun +4 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Author Correction to: Tube-dwelling in early animals exemplified by Cambrian scalidophoran worms
BMC Biology, 2022 Deng Wang +4 more
doaj +1 more source
Early life nutrition and brain development: breakthroughs, challenges and new horizons [PDF]
, 2022 Michael Georgieff
openalex +1 more source
Factors affecting early-life intestinal microbiota development.
Nutrition (Burbank, Los Angeles County, Calif.), 2020 Y. Vandenplas +9 more
semanticscholar +1 more source