Results 201 to 210 of about 20,037,007 (385)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Author Correction to: Tube-dwelling in early animals exemplified by Cambrian scalidophoran worms

BMC Biology, 2022
Deng Wang, Jean Vannier, Cédric Aria, Jie Sun, Jian Han   +4 more
doaj   +1 more source

Early-life stress and life

Aging, 2018
openaire   +2 more sources

Maternal-infant probiotic transmission mitigates early-life stress-induced autism in mice

Qing Li, Xin Qian, Huiyue Zhu, Jingyu Wang, Jiapan Sun, Zhiying Jin, Xinyu Tang, Yan Zhao, Gang Wang, Jianxin Zhao, Wei Chen, Peijun Tian   +11 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Vitamin D in early life and later risk of multiple sclerosis—A systematic review, meta-analysis

, 2019
Kamila Ismailova, Pratiksha Poudel, Alexandr Parlesak, Peder Frederiksen, Berit L. Heitmann   +4 more
openalex   +2 more sources

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

Nature Reviews Endocrinology, 2017
J. Braun
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Horn Growth and Reproduction in a Long-Lived Male Mammal: No Compensation for Poor Early-Life Horn Growth [PDF]

, 2014
Christian S. Willisch, Iris Biebach, Nelson Marreros, Marie‐Pierre Ryser‐Degiorgis, Peter Neuhaus   +4 more
openalex   +1 more source

Completing the Puzzle of My Early Life [PDF]

, 2015
Schuster-Southern, Kirk
core   +1 more source