Results 231 to 240 of about 19,801,094 (386)

Bridging early life trauma to difficult-to-treat depression: scoping review. [PDF]

BJPsych Bull
Paganin W, Signorini S, Sciarretta A.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Impact of psychosocial stress in early life on pace of aging in young adulthood. [PDF]

Clin Epigenetics
Su S, Lewis TT, Belsky DW, Liu Y, Zhang K, Snieder H, Wang X.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Genome-wide cross-trait analysis of heterogeneous outcomes in early life atopic dermatitis. [PDF]

Pediatr Allergy Immunol
Martin LJ, He H, Spagna D, Jenkins S, Grashel B, Chang WC, Williams L, Hammonds M, Johansson E, Sherenian MG, Biagini JM, Satish L, Kottyan L, Khurana Hershey GK.   +13 more
europepmc   +1 more source

The Continuity of Adversity: Negative Emotionality Links Early Life Adversity With Adult Stressful Life Events

Grace M. Brennan, Terrie E. Moffitt, Kyle J. Bourassa, HonaLee Harrington, Sean Hogan, Renate Houts, Richie Poulton, Sandhya Ramrakha, Avshalom Caspi   +8 more
openalex   +2 more sources

Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex [PDF]

Francesca Mottarlini, Beatrice Rizzi, Giorgia Targa, Valeria Buzzelli, Melania Di Trapano, Laura Rullo, Sanzio Candeletti, Roberto Ciccocioppo, Liana Fattore, Patrizia Romualdi, Fabio Fumagalli, Viviana Trezza, Lucia Caffino   +12 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Early-life viral infections and asthma: new cells and ideas. [PDF]

Curr Opin Pediatr
Lan J, McCray A, Brown E, Eddens T.
europepmc   +1 more source