Results 111 to 120 of about 541,912 (259)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Exploration of Development Parameters for IgG Microspheres Using an Automated Platform for High-Throughput Formulation Screening

Pharmaceuticals
Background/Objectives: PLGA/PLA microspheres are attractive candidates for depot delivery of protein therapeutics, but formulation development for antibodies remains challenging because protein encapsulation, burst release, stability, and polymer ...
Puneet Tyagi, Donyeil Hoy, Corina Badea-Mic, Anders Eckburg, Daniel Contaifer, Max Brodie, Kartik Raman, Kenan Pandza   +7 more
doaj   +1 more source

Immediate/Early Loading [PDF]

, 2020
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Clinical Utility of Early Viral Load Quantification [PDF]

Hepatology, 2000
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Early versus conventional loading for fully guided immediate implant placement in molar sites: a randomized controlled clinical study

International Journal of Implant Dentistry
Purpose To evaluate early versus conventional loading in immediate implants for molars. This study aims to answer the following PICO (Patient, Intervention, Comparison, and Outcome) question: In patients over 18 years of age, does early loading of ...
Kirollos H. Botros, Doaa Adel-Khattab, Abdelrahman K. Eldabe, Hala A. Abuel Ela   +3 more
doaj   +1 more source

Assessment of Immediate versus Delayed Loading Protocols in Single Tooth Anterior Implants

Journal of Pharmacy and Bioallied Sciences
Background: The timing of prosthetic loading plays a critical role in the long-term success of dental implants. In anterior maxillary regions, both functional and aesthetic outcomes are vital, and clinicians often debate between immediate and delayed ...
Narahari Ranganatha, Arvind Kumar Uikey, Richa Sahai, Sumit Bhatt, Aparna Deo Puranik, Zahara Bathool   +5 more
doaj   +1 more source

Loading of the artificial knee during early rehabilitation and physiotherapy

Bone & Joint Open
AimsThis retrospective observational study aimed to determine the in vivo joint loads in the knee after total knee arthroplasty during early postoperative rehabilitation involving different physiotherapy exercises and to analyze how these loads change over the first three weeks postoperatively.MethodsNine patients (six males, three females) with a ...
Nike, Schulle, Tobias, Winkler, Alwina, Bender, Srdan, Popovic, Clemens, Gwinner, Carsten, Perka, Georg, Duda, Philipp, Damm   +7 more
openaire   +2 more sources