Results 91 to 100 of about 541,912 (259)

Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone.

PLoS ONE, 2018
There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later
Stephanie A Borg, Harriet Buckley, Robert Owen, Ana Campos Marin, Yongtau Lu, Darryl Eyles, Damien Lacroix, Gwendolen C Reilly, Tim M Skerry, Nick J Bishop   +9 more
doaj   +1 more source

Implant loss and crestal bone loss in early loading versus delayed and immediate loading in edentulous mandibles. A systematic review and meta-analysis. [PDF]

J Clin Exp Dent, 2021
Pardal-Peláez B, Flores-Fraile J, Pardal-Refoyo JL, Montero J.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

About early loading in pelvic bone fractures

Kazan medical journal, 1969
Conservative treatment of pelvic fractures currently has two directions. On the one hand, the so-called "conservative-passive" method is widely used, well-developed and has many supporters, reflecting the desire to combine maximum rest with early function with late load.
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multiaxial rotational loading compromises the transition zone of the intervertebral disc: Ex vivo study using next‐generation bioreactors

Bioengineering & Translational Medicine
Bioreactors have become indispensable tools in spine research, enabling long‐term intervertebral disc culture under controlled biological and mechanical conditions.
Amra Šećerović, Aapo Ristaniemi, Francesco Crivelli, Sarah Heub, Mauro Alini, Gilles Weder, Diane Ledroit, Stephen J. Ferguson, Sibylle Grad   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Comparison of sandblasted and acid-etched surface implants and new hydrophilic surface implants in the posterior maxilla using a 3-month early-loading protocol: a randomized controlled trial. [PDF]

J Korean Assoc Oral Maxillofac Surg, 2021
Kim HG, Yun PY, Kim YK, Kim IH.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mechanical response of sandstone under variable loading rates and acoustic emission-based identification and early warning of fracture precursors

Meitan kexue jishu
Gob-side entry retaining with roof cutting is an important technique for achieving safe and efficient deep coal mining. However, under the combined effects of primary roadway excavation and secondary intensive mining-induced disturbances, severe ...
Xinzhu HUA, Chen LI, Peng YANG, Xiao LIU, Jiyuan YAN   +4 more
doaj   +1 more source