Results 61 to 70 of about 33,037 (314)

Comparison of Early Maladaptive Schema of Adult Children of Schizophrenic Parent With Adult Children of Healthy Parentalthy parent

, 2017
Objective: This project aimed to study early maladaptive schemas in adults with parents afflicted with schizophrenia. Methods: In a causal-comparative study, a sample of 39 adults with one schizophrenic parent as the experiment group and 40 students ...
Delaram Salehi, A. Abedin, M. R. Abadi
semanticscholar   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Developing a Structural Model of Pain Perception based on Early Maladaptive Schemata Mediated by Cognitive Emotion Regulation in people with Chronic Pain [PDF]

Iranian Evolutionary Educational Psychology Journal, 2023
Chronic pain affects the type of thinking, function and feeling of the individual and causes various limitations in the person's life.  This study aimed at developing a structural model of pain perception based on early maladaptive schemata mediated by ...
Mona Abbasi, Hayede Saberi, Afsaneh Taheri   +2 more
doaj  

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

The effectiveness of group schema therapy on early maladaptive schema of traditional and industrial addicts under methadone treatment

مجله علوم روانشناختی, 2019
Background: Much research has pointed to the effectiveness of individualized schema therapy on early maladaptive schemas of traditional and industrial drug users, but there is a research gap in the methadone treatment group in Birjand.
Ali Akbar Nakhee Shamahmood, Ali Arab, Ali Farnam   +2 more
doaj  

Emotion Differentiation as a Protective Factor Against Nonsuicidal Self-Injury in Borderline Personality Disorder

, 2013
Evidence that nonsuicidal self-injury (NSSI) serves a maladaptive emotion regulation function in borderline personality disorder (BPD) has drawn attention to processes that may increase risk for NSSI by exacerbating negative emotion, such as rumination ...
Berenson, Kathy R., Coifman, Karin G., Downey, Geraldine, Rafaeli, Eshkol, Zaki, Landon F.   +4 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Early Maladaptive Schemas in Depressed Women and Its Relationship with Depression

Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2013
Objective: Objective: Schemas are deep enduring cognitive structures that are the source of dysfunctional cognitions, emotions and behaviors, activate after critical incidents in depression.
Hacer Bolat KONUKÇU, Serkan AKKOYUNLU, M. Hakan TÜRKÇAPAR   +2 more
doaj   +1 more source

Psychosocial Outcomes in Long-Term Cochlear Implant Users [PDF]

, 2018
OBJECTIVES: The objectives of this study were to investigate psychosocial outcomes in a sample of prelingually deaf, early-implanted children, adolescents, and young adults who are long-term cochlear implant (CI) users and to examine the extent to ...
Castellanos, Irina, Kronenberger, William G., Pisoni, David B.   +2 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source