Results 241 to 250 of about 30,157 (379)

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu   +6 more
wiley   +1 more source

A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth

open access: yesHuman Brain Mapping, Volume 47, Issue 2, 01 February 2026.
Performance of five influential brain age estimation algorithms in two population‐based cohorts of youth. Brain age was quantified using estimates of brain structure, and performance was evaluated based on correlations with chronological age, error indices, sensitivity to demographic characteristics, scanning parameters, genetic similarity, and ...
Cleanthis Michael   +8 more
wiley   +1 more source

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment

open access: yesHuman Brain Mapping, Volume 47, Issue 2, 01 February 2026.
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Hu Xu   +9 more
wiley   +1 more source

Adolescent Vitamin D Supplementation Reverses Neuroplasticity and Motivational Deficits Induced by Developmental Alcohol Exposure and Early‐Life Stress

open access: yesInternational Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.
Adolescent vitamin D supplementation reverses behavioural and neuroplastic impairments induced by early‐life alcohol exposure and maternal separation in rats. Postnatal ethanol exposure (PND 4–10) and maternal separation stress (PND 2–14) led to motivational deficits and altered hippocampal plasticity.
Anelise Pereira Alves   +4 more
wiley   +1 more source

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