Results 91 to 100 of about 5,350,794 (320)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Stroke severity influences correlation of fibrinogen with early neurological deterioration after thrombolytic therapy

Journal of Stroke and Cerebrovascular Diseases
Background: To investigate the relationships between fibrinogen levels at baseline and 24 hours after intravenous thrombolysis (IVT) and early neurological deterioration (END); and to investigate whether stroke severity influences the correlation between
Shuhong Yu, MD, Jijun Shi, PhD, Shiping Guo, MD, Zhiliang Guo, PhD, Guodong Xiao, PhD   +4 more
doaj   +1 more source

Contribution of dehydration to END in acute ischemic stroke not mediated via coagulation activation

Brain and Behavior, 2019
Objective Dehydration is a risk factor for early neurological deterioration (END) after ischemic stroke, yet the underlying mechanism is unclear. Outbalanced coagulation activation may contribute to ischemia progression, concurrently with dehydration ...
Zhu Shi, Wei C Zheng, Heng Yang, Xiao L. Fu, Wei Y. Cheng, Wei J. Yuan   +5 more
doaj   +1 more source

The Relationship of the Type of Intracerebral Hemorrhage to Early Disease Evolution and Long-Term Prognosis After r-tPA Thrombolysis

Clinical and Applied Thrombosis/Hemostasis, 2021
To investigate the relationship of different subtypes of intracerebral hemorrhage (ICH) to early disease evolution and long-term prognosis in patients with acute cerebral infarction after intravenous recombinant tissue plasminogen activator(r-tPA ...
Ting Yang MSc, Hongfei Jing MSc, Yungang Cao MSc, Xianda Lin MSc, Jueyue Yan MSc, Meijuan Xiao MSc, Xiaoyan Huang MSc, Zicheng Cheng MSc, Zhao Han MSc   +8 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Tension pneumocephalus - a rare but treatable cause of rapid neurological deterioration in traumatic brain injury. A case report [PDF]

, 2011
Pneumocephalus is a frequent complication following head injury and craniotomies. It can become an acute neurosurgical emergency when associated with raised intracranial pressure and neurological deterioration.
Komolafe, EO, Faniran, E
core   +1 more source

Clinical determinants of neurologic worsening in various stroke subtypes

Бюллетень сибирской медицины, 2008
With the purpose of clinical determinants definition of neurological deterioration in patients with an ischemic stroke and its prognostic value, the retrospective analysis of case records of 253 patients with first in a life stroke was carried out and ...
N. V. Oleksyuk, V. V. Zudin, M. A. Sychyova, Yu. T. Kouryachenko   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Ultra-early neurological deterioration following a brain arteriovenous malformation rupture

Frontiers in Neurology
PurposeThis study aims to explore the impact of ultra-early neurological deterioration (U-END) on the outcome (mortality and poor neurological status) following a brain arteriovenous malformation (BAVM) rupture and identify determinants of U-END ...
Eimad Shotar, Eimad Shotar, Pierre-Marie Chiaroni, Pierre-Marie Chiaroni, Idriss Haffaf, Jonathan Cortese, Alice Jacquens, Alice Jacquens, Lorenzo Garzelli, Julien Allard, Mahmoud Elhorany, Mahmoud Elhorany, Caroline Amouyal, Bertrand Mathon, Bertrand Mathon, Aurélien Nouet, Kévin Premat, Stéphanie Lenck, Nader-Antoine Sourour, Vincent Degos, Vincent Degos, Frédéric Clarençon, Frédéric Clarençon   +22 more
doaj   +1 more source