Results 121 to 130 of about 5,350,794 (320)

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Prehospital neurological deterioration in stroke [PDF]

, 2018
Background and purposePatients with stroke can experience neurological deterioration in the prehospital setting. We evaluated patients with stroke to determine factors associated with prehospital neurological deterioration (PND).MethodsAmong the Greater ...
Kathleen Alwell, Opeolu Adeoye, Sharyl Martini, Sucharew, Heidi, Brett M Kissela, Alwell, Kathleen, Martini, Sharyl, Ferioli, Simona, Dawn O Kleindorfer, Charles J Moomaw, Flaherty, Matthew L., Heidi Sucharew, Simona Ferioli, Moomaw, Charles J., Mackey, Jason, Woo, Daniel, Jason Mackey, Daniel Woo, McMullan, Jason, Slavin, Sabreena J., Sabreena J Slavin, Jason McMullan, De Los Rios La Rosa, Felipe, Kissela, Brett M., Felipe De Los Rios La Rosa, Adeoye, Opeolu, Kleindorfer, Dawn O., Matthew L Flaherty   +27 more
core   +1 more source

Early neurological deterioration before endovascular treatment in patients with mild stroke. MINORCAT-END-EVT study

Journal of Stroke and Cerebrovascular Diseases
Background and Purpose: The management of patients with anterior circulation large vessel occlusion (LVO) presenting with mild neurological symptoms remains a matter of debate.
Maria Àngels Font, MD, Sonia María García-Sánchez, MD, Juan José Mengual, MD, Carla Avellaneda, MDPhD, Sandra Boned, MDPhD, Antonio Doncel-Moriano, MD, Xabier Urra, MDPhD, Pol Camps-Renom, MDPhD, Natalia Pérez de la Ossa, MDPhD, Mikel Terceño, MDPhD, Barbara Yugueros, MD, Xavier Ustrell, MD, Francisco Purroy, MDPhD, Ana Rodríguez-Campello, MD, Carlos Molina, MDPhD, Jerzy Krupinski, MDPhD, Georgina Figueras Aguirre, MD, Mariona Baraldes, MD, Xavier Jiménez-Fàbrega, MD, Mercè Salvat-Plana, RN, Roberto Elosua, MDPhD, Sonia Abilleira, MDPhD, Pere Cardona, MD, Manuel Gómez-Choco, MDPhD   +23 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers

Neuropsychiatric Disease and Treatment, 2022
Avan Sabir Rashid,1,2 Yumin Huang-Link,1,2 Marcus Johnsson,1,2 Simon Wetterhäll,1,2 Helena Gauffin1,2 1Department of Biomedical and Clinical Sciences (BKV), Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden; 2Department of ...
Sabir Rashid A, Huang-Link Y, Johnsson M, Wetterhäll S, Gauffin H   +4 more
doaj  

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

The association between early neurological deterioration and whole blood purine concentration during acute stroke [PDF]

, 2019
BackgroundEarly neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxia, may
Roffe
core   +1 more source

Imaging biomarker associated with early neurological deterioration in isolated pontine infarction

Frontiers in Neurology
ObjectiveTo investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.Methods107 patients ...
Xiaowei Song, Feifei He, Duoduo Hou, Hongliang Zhao, Chenming Wei, Le Chen, Zhuoma Pengmao, Jian Wu, Jian Wu   +8 more
doaj   +1 more source

The Ischemic Stroke Predictive Risk Score Predicts Early Neurological Deterioration

Journal of Stroke and Cerebrovascular Diseases, 2016
Although early neurological deterioration (END) during the acute stroke period is known to be directly associated with poor short- and long-term outcomes, few studies have investigated the ability to predict END. The aim of this study was to investigate whether there are differences in the occurrence of END according to the ischemic stroke predictive ...
Young Dae Kim, Hye-Yeon Choi, Yo Han Jung, Joonsang Yoo, Hyo Suk Nam, Dongbeom Song, Ji Hoe Heo, Gustavo Saposnik   +7 more
openaire   +3 more sources