Results 51 to 60 of about 1,485,041 (265)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Two new positive psychosocial measures for persons living with dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Differences in adaptive strategies used by individuals and families living with dementia have the potential to impact day‐to‐day well‐being.
Sheila L. Molony, Sam Fazio, Kimberly Van Haitsma, Richard Feinn, Joseph Montminy, Maureen Rulison, Ricci Sanchez, Sheryl Zimmerman   +7 more
doaj   +1 more source

Early-onset total cholesterol abnormality is associated with gray matter atrophy and decreased microstructural integrity

Journal of Lipid Research
The occurrence of abnormal total cholesterol (TC) can gradually and persistently induce brain damage. Early-onset TC abnormality indicates the accumulation of risks.
Ling Yang, Ying Hui, Mingze Xu, Yanbo Liang, Qunya Qi, Li Yu, Zhenchang Wang, Shouling Wu, Ning Wu, Yuntao Wu, Han Lv   +10 more
doaj   +1 more source

TP53 rs1042522 polymorphism and early-onset breast cancer

Journal of Research in Medical Sciences, 2020
Background: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms.
Irmak Icen-Taskin, Sevgi Irtegun-Kandemir, Omer Munzuroglu   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

What is ‘early onset dementia’? [PDF]

Psychogeriatrics, 2009
AbstractThere are two types of dementia with early onset: (i) presenile dementias; and (ii) senile dementias with early onset. Most patients who develop dementia before 65 years of age have Alzheimer's disease (AD). The remainder are likely to have vascular dementia (VaD), frontotemporal dementia, head injury, alcohol intoxication, or metabolic ...
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Early Onset Charcot-Marie-Tooth Disease

Pediatric Neurology Briefs, 2005
The clinical signs and genetic analysis of early-onset Charcot-Marie-Tooth disease (CMT) in a 2-year-old boy and members of his family are reported from the Academic Medical Center, Amsterdam, and Sophia Children’s Hospital, Rotterdam, the Netherlands.
J Gordon Millichap
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Clinical Characteristics of Early-Onset and Late-Onset Leigh Syndrome

Frontiers in Neurology, 2020
Background: Leigh syndrome (LS) is the most common pediatric mitochondrial diseases caused by MRC defect. LS patients typically have onset age before 2 years old and have various clinical features.
Chan-Mi Hong, Ji-Hoon Na, Soyoung Park, Young-Mock Lee   +3 more
doaj   +1 more source