Results 101 to 110 of about 7,641,894 (297)

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao, Xinhua Feng, Aifu Lin, Lei Zhao, Stephanie Roessler, Junfang Ji   +14 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Middle-aged patients with an MRI-verified medial meniscal tear report symptoms commonly associated with knee osteoarthritis: A cross-sectional study of 199 patients

Acta Orthopaedica, 2017
Background and purpose — No consensus exists on when to perform arthroscopic partial meniscectomy in patients with a degenerative meniscal tear. Since MRI and clinical tests are not accurate in detecting a symptomatic meniscal lesion, the patient’s ...
Kristoffer B Hare, L Stefan Lohmander, Nina Jullum Kise, May Arna Risberg, Ewa M Roos   +4 more
doaj   +1 more source

Sonographic Imaging of Meniscal Subluxation in Patients with Radiographic Knee Osteoarthritis

Journal of the Formosan Medical Association, 2007
This study was undertaken to describe the sonographic features of meniscal sub-luxation in the weight-bearing position and to determine any association between meniscal subluxation and radiographic osteoarthritis.
Chun-Hung Ko, Kam-Kong Chan, Hui-Ling Peng   +2 more
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

The Anatomical Record, EarlyView.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source

Inflammatory Profiling in Early Osteoarthritis

, 2018
Osteoarthritis (OA) is one of the most common chronic diseases worldwide which can lead to disability. There is a desperate need for the efficient and reliable detection of OA at the early stage when patients are likely to benefit most from disease interventions. It has been shown in previous studies that inflammation plays important roles in cartilage
openaire   +3 more sources

Clinical Physical Exam Shows High Sensitivity for Detecting Labral Tears in Individuals With Femoroacetabular Impingement Syndrome

Arthroscopy, EarlyView.
Purpose To determine the diagnostic performance of the combined use of radiographs and physical exam findings, compared with magnetic resonance arthrography (MRA) alone, for the primary diagnosis of labral tears in individuals with femoroacetabular impingement syndrome.
Carson Halliwell, Rebecca Moyer, George Konstantinidis, Eyal Amar, Ivan Wong   +4 more
wiley   +1 more source

Long‐Term Outcomes Following Anatomic Double‐Bundle Versus Single‐Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Autograft: A Randomized Controlled Trial With an Average 14‐Year Follow‐Up

Arthroscopy, EarlyView.
Purpose To compare the clinical and radiographic outcomes—particularly the long‐term development of osteoarthritis—14 years after anterior cruciate ligament (ACL) reconstruction between anatomic double‐bundle (DB) and anatomic single‐bundle (SB) techniques.
Dlshad Qadir, Ninni Sernert, Lars Rostgard‐Christensen, Neel Desai, Mattias Ahldén, Jüri‐Toomas Kartus, Ioannis Karikis   +6 more
wiley   +1 more source