Results 21 to 30 of about 7,641,894 (297)

Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model

Biology, 2020
Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects.
Girish Pattappa, Jonas Krueckel, Ruth Schewior, Dustin Franke, Alexander Mench, Matthias Koch, Johannes Weber, Siegmund Lang, Christian G. Pfeifer, Brian Johnstone, Denitsa Docheva, Volker Alt, Peter Angele, Johannes Zellner   +13 more
doaj   +1 more source

Therapeutic Exercise and Conservative Injection Treatment for Early Knee Osteoarthritis in Athletes: A Scoping Review

Medicina, 2022
Background and Objectives: Recent evidence highlighted a higher prevalence of knee osteoarthritis (kOA) among young and former ex-professional athletes.
Lucrezia Tognolo, Maria Chiara Maccarone, Stefania De Trane, Anna Scanu, Stefano Masiero, Pietro Fiore   +5 more
doaj   +1 more source

Role of Musculoskeletal Ultrasound and Matrix Metalloprteinase-2 serum Level in the Diagnosis of early Knee Osteoarthritis [PDF]

International Journal of Medical Arts, 2020
Background: Osteoarthritis (OA) is the most common joint disease, causing disability and reduction of quality of life and participation in social activity.
Tarek Nasrallah, Hesham Abdel wahab, Mostafa Shakweer, Sabah Abd Al Raheem, Hanan Mehesin   +4 more
doaj   +1 more source

Identification of serum micro-RNAs of early knee osteoarthritis in a cohort of Egyptian patients

Alexandria Journal of Medicine, 2023
Background Osteoarthritis (OA), is a prevalent low-grade inflammatory synovial joint disease characterized by progressive cartilage degradation and alteration of the entire joint. Knee OA (KOA) is the commonest form of OA.
Anna Abou-Raya, Mohamed Rizk, Eman AbdelGhani, Nermen AbdelMegid   +3 more
doaj   +1 more source

OSTEOARTHRITIS: CURRENT CLINICAL CONCEPT AND SOME PROMISING THERAPEUTIC APPROACHES

Научно-практическая ревматология, 2018
In recent years, there has been a trend toward changing the clinical concept of osteoarthritis (OA). This disease has been considered as an age-related disease and the long-term result of a current pathological process for a very long time. However, many
A. E. Karateev, A. M. Lila
doaj   +1 more source

Poor functional performance 1 year after ACL reconstruction increases the risk of early osteoarthritis progression

British Journal of Sports Medicine, 2020
Background Not meeting functional performance criteria increases reinjury risk after ACL reconstruction (ACLR), but the implications for osteoarthritis are not well known. Objective To determine if poor functional performance post-ACLR is associated with
B. Patterson, A. Culvenor, C. Barton, A. Guermazi, J. Stefanik, H. Morris, T. Whitehead, K. Crossley   +7 more
semanticscholar   +1 more source

Inflammatory priming with IL-1β promotes the immunomodulatory behavior of adipose derived stem cells

Frontiers in Bioengineering and Biotechnology, 2022
Inflammatory processes contribute to osteoarthritis (OA) severity and progression. Mesenchymal stem cells, particularly those derived from adipose tissue (ASCs), are able to sense and control the inflammatory environment.
Alessandra Colombini, Francesca Libonati, Davide Cangelosi, Silvia Lopa, Paola De Luca, Domenico Antonio Coviello, Matteo Moretti, Matteo Moretti, Matteo Moretti, Matteo Moretti, Laura de Girolamo   +10 more
doaj   +1 more source

Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: From predictive fiction toward reality

Frontiers in Medicine, 2022
The purpose of the present study is to predict by bioinformatics the activity of the extracellular vesicle (EV)-embedded micro RNA (miRNAs) secreted by cartilage cells (CCs), adipose tissue-derived- (ASCs), and bone marrow-derived stem cells (BMSCs) and ...
Alessandra Colombini, Francesca Libonati, Silvia Lopa, Enrico Ragni, Paola De Luca, Luigi Zagra, Federico Sinigaglia, Matteo Moretti, Matteo Moretti, Matteo Moretti, Matteo Moretti, Laura de Girolamo   +11 more
doaj   +1 more source

Towards secondary prevention of early knee osteoarthritis [PDF]

RMD Open, 2018
Osteoarthritis (OA) of the knee is the most common arthritic disease, yet a convincing drug treatment is not available. The current narrative review focuses on integration of scientific evidence and professional experience to illustrate which management approaches can be taken for prototypical individual patient profiles with early knee OA.
Mahmoudian, Armaghan, Van Assche, Dieter, Herzog, Walter, Luyten, Frank P.   +3 more
openaire   +2 more sources

Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis

Cells, 2019
Osteoarthritis (OA) is a degenerative condition that involves the production of inflammatory cytokines (e.g., interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)) that stimulate degradative enzymes, matrix
Girish Pattappa, Ruth Schewior, Isabelle Hofmeister, Jennifer Seja, Johannes Zellner, Brian Johnstone, Denitsa Docheva, Peter Angele   +7 more
doaj   +1 more source