Results 41 to 50 of about 7,641,894 (297)

Integrated single-cell and bulk RNA sequencing analysis reveal immune-related biomarkers in postmenopausal osteoporosis

Heliyon
Background: Postmenopausal osteoporosis (PMOP) represents as a significant health concern, particularly as the population ages. Currently, there is a paucity of comprehensive descriptions regarding the immunoregulatory mechanisms and early diagnostic ...
Shenyun Fang, Haonan Ni, Qianghua Zhang, Jilin Dai, Shouyu He, Jikang Min, Weili Zhang, Haidong Li   +7 more
doaj   +1 more source

Cartilage lesions are not the main factor influencing pain and functional impairment in early knee osteoarthritis: a multivariate analysis on intra- and extra-articular factors affecting symptoms in over 200 knees

Bone & Joint Open
Aims: To investigate the correlation between symptoms, in terms of pain and functional scores, and the extent of cartilage damage as well as other intra- and extra-articular factors in patients suffering from early knee osteoarthritis (OA).
Luca Bianco Prevot, Alessandro Bensa, Pietro S Randelli, Giuseppe Filardo   +3 more
doaj   +1 more source

T1 and T2 mapping of articular cartilage and menisci in early osteoarthritis of the knee using 3-Tesla magnetic resonance imaging

Polish Journal of Radiology, 2019
Purpose 3-Tesla magnetic resonance imaging (MRI) T1 and T2 mapping to detect and quantify cartilage matrix and meniscal degeneration between normal healthy volunteers and early osteoarthritis patients.
S. Mittal, G. Pradhan, Sapna Singh, Radhika Batra   +3 more
semanticscholar   +1 more source

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

eLife
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration.
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki   +6 more
doaj   +1 more source

Current and novel theranostic modalities for knee osteoarthritis

Сеченовский вестник, 2021
Osteoarthritis is the second most common disorder after heart disease. This progressive degenerative disease affects the knee joint more than any others. The exact etiology of knee osteoarthritis is not clear, however, there are many predisposing factors
B. Sadri, Sh. Nouraein, N. Hossein-Khannazer, J. Mohammadi, M. Vosough   +4 more
doaj   +1 more source

Does total hip arthroplasty benefit patients with minimal radiological osteoarthritis?

Bone & Joint Open
Aims: The effectiveness of total hip arthroplasty (THA) for patients with no or minimal radiological signs of osteoarthritis (OA) is unclear. In this study, we aimed to: 1) assess the outcome of such patients; 2) identify patient comorbidities and CT or
Kartik Logishetty, Jeroen C. F. Verhaegen, Shannon Tse, Tim Maheswaran, Max Fornasiero, Hariharan Subbiah Ponniah, Jonathan B. Hutt, Johan D. Witt   +7 more
doaj   +1 more source

Hip Morphology–Based Osteoarthritis Risk Prediction Models: Development and External Validation Using Individual Participant Data From the World COACH Consortium

Arthritis Care &Research, EarlyView.
Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Jinchi Tang, Harbeer Ahedi, Nigel K. Arden, Sita M. A. Bierma‐Zeinstra, Cindy G. Boer, Flavia M. Cicuttini, Timothy F. Cootes, David T. Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E. Lane, Claudia Lindner, Joyce B. J. van Meurs, Andrea Mosler, Amanda E. Nelson, Michael C. Nevitt, Edwin H. Oei, Jos Runhaar, Harrie Weinans, Jesse H. Krijthe, Rintje Agricola   +26 more
wiley   +1 more source

Runx1 protects against the pathological progression of osteoarthritis

Bone Research, 2021
Runt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.
Chenchen Zhou, Yujia Cui, Yueyi Yang, Daimo Guo, Demao Zhang, Yi Fan, Xiaobing Li, Jing Zou, Jing Xie   +8 more
doaj   +1 more source

Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects

Diagnostics, 2022
Knee osteoarthritis is one of the leading causes of chronic disability worldwide and is a significant social and economic burden on healthcare systems; hence it has become essential to develop methods to identify patients at risk for developing knee ...
Carlo A. Mallio, Caterina Bernetti, Francesco Agostini, Massimiliano Mangone, Marco Paoloni, Gabriele Santilli, Francesca Maria Martina, Carlo C. Quattrocchi, Bruno Beomonte Zobel, Andrea Bernetti   +9 more
doaj   +1 more source

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records From an Integrated Health System

Arthritis Care &Research, EarlyView.
Objective This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source