Results 51 to 60 of about 7,641,894 (297)

New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis

Arthritis Research & Therapy, 2017
Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes ...
Heng Li, Dan Wang, Yong-jian Yuan, J. Min   +3 more
semanticscholar   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Osteophyte growth in early thumb carpometacarpal osteoarthritis [PDF]

Osteoarthritis and Cartilage, 2019
Osteophyte formation is a critical part of the degeneration of a joint with osteoarthritis (OA). While often qualitatively described, few studies have succeeded in quantifying osteophyte growth over time. Using computed tomography (CT) image data from a longitudinal, observational study of thumb carpometacarpal (CMC) OA, our aim was to quantify ...
J J, Crisco, A M, Morton, D C, Moore, L G, Kahan, A L, Ladd, A-P C, Weiss   +5 more
openaire   +2 more sources

Testing a Personalized Approach to Chronic Low Back Pain: A Randomized Controlled Trial in Older Veterans

Arthritis Care &Research, EarlyView.
Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner, Angela Gentili, Meika A. Fang, Edward Garay, Laura Lawson, Lenore Joseph, Cathy C. Lee, Michelle I. Rossi, Beverly Thorn, Subashan Perera   +9 more
wiley   +1 more source

A warning machine learning algorithm for early knee osteoarthritis structural progressor patient screening

Therapeutic Advances in Musculoskeletal Disease, 2021
Aim: In osteoarthritis (OA) there is a need for automated screening systems for early detection of structural progressors. We built a comprehensive machine learning (ML) model that bridges major OA risk factors and serum levels of adipokines/related ...
Hossein Bonakdari, Afshin Jamshidi, Jean-Pierre Pelletier, François Abram, Ginette Tardif, Johanne Martel-Pelletier   +5 more
doaj   +1 more source

Knee Osteoarthritis Detection and Classification Using X-Rays

IEEE Access, 2023
Knee osteoarthritis is a common form of arthritis, a chronic and progressive disease recognized by joint space narrowing, osteophyte formation, sclerosis, and bone deformity that can be observed using radiographs.
Tayyaba Tariq, Zobia Suhail, Zubair Nawaz   +2 more
doaj   +1 more source

Management of Early Osteoarthritis

, 2021
Osteoarthritis (OA) is a chronic degenerative joint disease of dynamic pathology with multiple etiologies. It involves progressive process of softening, loss of articular cartilage, subchondral bone sclerosis, development of osteophytes, and cyst formation.
openaire   +3 more sources

Serum protein signatures detect early radiographic osteoarthritis [PDF]

Osteoarthritis and Cartilage, 2009
To test the hypothesis that early knee and hand OA development is characterized by detectable changes in serum proteins relevant to inflammation, cell growth, activation, and metabolism several years before OA becomes radiographically evident.
Ling, S.M., Patel, D.D., Garnero, P., Zhan, M., Vaduganathan, M., Muller, D., Taub, D., Bathon, J.M., Hochberg, M., Abernethy, D.R., Metter, E.J., Ferrucci, L.   +11 more
openaire   +2 more sources

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source