Results 81 to 90 of about 7,641,894 (297)

Cartilage-Specific ¹⁸F-NaF Uptake in Rat Models: A Multimodal In Vitro and Ex Vitro Comparative Study with ^99mTc-MDP

Biomedicines
Background: 18F-NaF and 99mTc-MDP are widely used bone imaging tracers, but their comparative uptake in bone versus cartilage is unclear. This study aimed to directly compare these patterns in rats to guide musculoskeletal molecular imaging.
Qingxiao Li, Jianpeng Gao, Yiqun Wang, Yaoyao Song, Liwei Liu, Cong Zhang, Ming Li, Haodan Dang, Jiahe Tian   +8 more
doaj   +1 more source

Metabolomics as a promising tool for early osteoarthritis diagnosis

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017
Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its ...
Eduardo Branco de Sousa, G. D. S. S. Junior, M. L. Duarte, V. M. Neto, D. P. Aguiar   +4 more
semanticscholar   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

Arthritis Research & Therapy, 2017
BackgroundAtsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis .
Jian-lu Wei, W. Fu, Yuan Ding, A. Hettinghouse, M. Lendhey, R. Schwarzkopf, O. Kennedy, Chuan-ju Liu   +7 more
semanticscholar   +1 more source

Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues

Advanced Science, EarlyView.
This study presents a novel 4D bioprinting platform for engineering biomimetic musculoskeletal grafts. By tuning the mechanical properties of support baths, we enhance tissue fusion, collagen alignment, and cell differentiation. Using this strategy, we successfully fabricate scaled‐up, anisotropic tissues such as meniscus, articular cartilage, and ...
Francesca D. Spagnuolo, Gabriela S. Kronemberger, Daniel J. Kelly   +2 more
wiley   +1 more source

From mobility to intimacy: assessing the effects of periacetabular osteotomy on sexual function in patients with hip dysplasia

Bone & Joint Open
Aims: Developmental dysplasia of the hip (DDH) often leads to early osteoarthritis, causing pain and functional limitations that may impair sexual function.
Vincent J. Leopold, Sebastian Hardt, Susanne Bärtl, Carsten Perka, Luis A. Becker   +4 more
doaj   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis

Journal of Immunology Research, 2015
Osteoarthritis is a common and debilitating joint disease that affects up to 30 million Americans, leading to significant disability, reduction in quality of life, and costing the United States tens of billions of dollars annually.
Adrese M. Kandahari, Xinlin Yang, Abhijit S. Dighe, Dongfeng Pan, Quanjun Cui   +4 more
doaj   +1 more source

Osteoarthritis of the hands in early populations [PDF]

Rheumatology, 1996
A study of the distribution of osteoarthritis of the hands was carried out in a series of 168 skeletons (77 males, 87 females, four unknown sex) from archaeological sites in England. There were substantial differences in the distribution of the disease between the sexes, but the only significant differences between the hands were shown for the second ...
openaire   +2 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source