Results 91 to 100 of about 5,083,312 (279)

Arrhythmias due to Inherited and Acquired Abnormalities of Ventricular Repolarization

, 2019
Several acquired and congenital disease conditions and many cardiac and noncardiac drugs affect ventricular repolarization and increase susceptibility to ventricular arrhythmias.
Johny H., Lunati M., Pappone C., Bagliani G., Cecchi F., Locati E. T.   +5 more
core   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Reduced sodium current in the lateral ventricular wall induces inferolateral J-waves

Frontiers in Physiology, 2016
Background: J-waves in inferolateral leads are associated with a higher risk for idiopathic ventricular fibrillation. We aimed to test potential mechanisms (depolarization or repolarization dependent) responsible for inferolateral J-waves.
Veronique Marlinde Frederica Meijborg, Veronique Marlinde Frederica Meijborg, Mark Potse, Mark Potse, Mark Potse, Chantal E Conrath, Charly NW Belterman, Charly NW Belterman, Jacques MT De Bakker, Jacques MT De Bakker, Jacques MT De Bakker, Ruben Coronel, Ruben Coronel   +12 more
doaj   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Síndromes de la onda J J wave syndromes

Revista Cubana de Investigaciones Biomédicas, 2012
Se realizó una revisión sobre los aspectos más novedosos y polémicos de los síndromes de la onda J, que incluyó el síndrome de repolarización precoz, la fibrilación ventricular idiopática y la muerte súbita nocturna inexplicable.
Annerys Méndez Rosabal
doaj  

Electrocardiographic early repolarization is associated with future ventricular arrhythmia after acute myocardial infarction—Systematic Review and Meta‐Analysis

Journal of Arrhythmia, 2019
Background Early repolarization (ER) has been linked to ventricular arrhythmia (VA) and sudden cardiac death in patients without structural heart disease.
Raymond Pranata, Emir Yonas, Rachel Vania, Sunu Budhi Raharjo, Bambang Budi Siswanto, Budhi Setianto   +5 more
doaj   +1 more source

Early Repolarization Associated With Ventricular Arrhythmias in Patients With Chronic Coronary Artery Disease

, 2010
Background— Early repolarization, indicated on the standard 12-lead ECG, has recently been associated with idiopathic ventricular fibrillation in patients without structural heart disease.
Reddy, Vikram, Goldberger, Jeffrey J, Jason Ng, Vikram Reddy, Jeffrey J. Goldberger, Ng, Jason, Alawi A. Alsheikh-Ali, Patel, Ravi B, Chokshi, Moulin, Ravi B. Patel, Leonard Ilkhanoff, Link, Mark S, Alan H. Kadish, Nguyen, Tuan, Tuan Nguyen, Moulin Chokshi, Haris Subacius, Parikh, Kishan, Mark S. Link, Ilkhanoff, Leonard, Kadish, Alan H, Kishan Parikh, Alsheikh-Ali, Alawi A, Subacius, Haris   +23 more
core   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source