Results 61 to 70 of about 4,740,981 (276)

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

Early Repolarization and the Severity of Coronary Artery Disease: A Case-control Study

Caspian Journal of Internal Medicine, 2021
Background: Early repolarization (ER) is a common finding of the routine electrocardiogram (ECG). The ER usually considered a benign ECG finding, nevertheless a controversy.
Roholla Hemmati, Yousef Mohsenzadeh, Shirvan Salaminia, Fatemeh Sayehmiri   +3 more
doaj  

Analysis of the spatial and transmural dispersion of repolarization and late potentials derived using signal-averaged vector-projected 187-channel high-resolution electrocardiogram in patients with early repolarization pattern

Journal of Arrhythmia, 2014
Background: Electrophysiological characteristics of early repolarization syndrome (ERS), i.e., the spatial and transmural dispersion of ventricular repolarization and ventricular late potentials can be evaluated using a signal-averaged vector-projected ...
Kimie Ohkubo, MD, Ichiro Watanabe, MD, Yasuo Okumura, MD, Kazumasa Sonoda, MD, Naoko Sasaki, MD, Rikitake Kogawa, MD, Keiko Takahashi, MD, Toshiko Nakai, MD, Satoshi Kunimoto, MD, Yuji Kasamaki, MD, Atsushi Hirayama, MD   +10 more
doaj   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Sudden cardiac arrest associated with early repolarization.

, 2008
BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a ...
Haïssaguerre, M;Derval, N;Sacher, F;Jesel, L;Deisenhofer, I;de Roy, L;Pasquié, JL;Nogami, A;Babuty, D;Yli-Mayry, S;De Chillou, C;Scanu, P;Mabo, P;Matsuo, S;Probst, V;Le Scouarnec, S;Defaye, P;Schlaepfer, J;Rostock, T;Lacroix, D;Lamaison, D;Lavergne, T;Aizawa, Y;Englund, A;Anselme, F;O'Neill, M;Hocini, M;Lim, KT;Knecht, S;Veenhuyzen, GD;Bordachar, P;Chauvin, M;Jaïs, P;Coureau, G;Chene, G;Klein, GJ;Clémenty, J
core   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs

Journal of Pharmacological Sciences, 2017
Fatal cases with the use of atypical antipsychotic drug paliperidone have been reported; however, there was no clinical report describing paliperidone-induced torsade de pointes.
Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T. Naito, Atsushi Sugiyama   +9 more
doaj   +1 more source

Effect of Acute Myocardial Ischemia on Inferolateral Early Repolarization. [PDF]

, 2020
BACKGROUND Inferolateral early repolarization (ER) is associated with an increase in arrhythmic risk, particularly in the presence of myocardial ischemia. OBJECTIVE To determine the effect of myocardial ischemia on ER.
Heg, Dik, Roten, Laurent, Branca, Mattia, Seiler, Christian, Stoller, Michael, Boehler, Alexander, Bloch, Nando   +6 more
core   +3 more sources

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

THE ASSOCIATION OF RISK FACTORS FOR ATHEROSCLEROSIS AND POLYMORPHISM OF THE ADRB1 GENE WITH PRO-ARRHYTHMIC ELECTROCARDIOGRAPHIC PATTERNS IN THE GENERAL POPULATION OF NOVOSIBIRSK

Атеросклероз, 2018
The dangerous electrophysiological shifts in the myocardium, with the exception of rare congenital canalopathies, are overwhelmingly secondary, being a consequence of various pathological conditions.
A. A. Kuznetsov, A. A. Kuznetsova, T. I. Batluk, V. N. Maksimov, M. I. Voevoda, S. K. Malyutina, Yu. P. Nikitin   +6 more
doaj   +1 more source