Results 121 to 130 of about 22,736,691 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Preschool curriculum review

open access: yes, 2023
In order to meet the requirements of Act 284 (Read to Succeed), the Office of Early Learning and Literacy conducted a review process to approve curricula which meet the criteria outlined in legislation.
South Carolina State Department of Education. Office of Early Learning and Literacy   +1 more
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Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

2018-2023 strategic plan for South Carolina State University

open access: yes, 2023
South Carolina State University publishes strategic plans and updates to provide a comprehensive framework from which the university will continue to operationalize its mission, which is to prepare highly skilled, competent and socially aware graduates ...
South Carolina State University
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GERMANY’S YOUTH POLICY IN 1949 – 1957 AND ITS ACTORS: GENERAL OVERVIEW

open access: yesВестник Кемеровского государственного университета, 2015
The paper is devoted to the questions of formation and institutionalization of the youth policy in the early Federal Republic of Germany. The significance of the youth policy, its main features and trends are shown.
E. S. Lyubomirova
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Early childhood professional learning plan legislative report

open access: yes, 2020
submitted by the Early Learning Division.Title from PDF cover (viewed on April 12, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

«Owners of the sands»: sand protection works on the lands of the nomadic peoples of Southern Russia (Nogais, Kalmyks and Turkmens) in the XIX – early XX centuries

open access: yesКавказология
The publication examines the organization of sand protection works carried out in semi–desert zones of Southern Russia in the XIX - early XX centuries.
Aigul T. Dzhumagulova
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

New state agency beginning July 1, 2023. Spanish

open access: yes, 2023
This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government ...

core  

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