Results 81 to 90 of about 12,738,743 (318)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials

BMC Medical Research Methodology, 2011
Background Response rate (RR), the most common early means of assessing oncology drugs, is not suitable as the sole endpoint for phase II trials of drugs which induce disease stability but not regression.
Goffin John R, Pond Greg R
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ion stopping in dense plasma target for high energy density physics [PDF]

, 2010
The basic physics of nonrelativistic and electromagnetic ion stopping in hot and ionized plasma targets is thoroughly updated. Corresponding projectile-target interactions involve enhanced projectile ionization and coupling with target free electrons ...
Hasegawa, Jun, Sharkov, Boris Y., Deutsch, Claude, Chabot, Marin, Golubev, Alexey A., Ogawa, Masao, Bimbot, René, Jacoby, Joachim, Couillaud, Christophe, Mintsev, Victor, Della-Negra, Serge, Hoffmann, Dieter H. H., Wahl, H., Weyrich, Karin, Gardes, Daniel, Fleurier, Claude, Fertman, Alexander, Maynard, Gilles, Rivet, Marie-France, Tahir, Naeem Ahmad, Rosmej, Olga N., Fortov, Vladimir E., Oguri, Yoshiyuki   +22 more
core  

Why Did I Stop? Barriers and Facilitators to Uptake and Adherence to ART in Option B+ HIV Care in Lilongwe, Malawi. [PDF]

PLoS ONE, 2016
Causes for loss-to-follow-up, including early refusals of and stopping antiretroviral therapy (ART), in Malawi's Option B+ program are poorly understood. This study examines the main barriers and facilitators to uptake and adherence to ART under Option B+
Maria H Kim, Amy Zhou, Alick Mazenga, Saeed Ahmed, Christine Markham, Gerald Zomba, Katie Simon, Peter N Kazembe, Elaine J Abrams   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Early childhood flexibility practices and patterns: report 2014 [PDF]

, 2014
The Early childhood flexibility practices and patterns report highlights recommendations and future directions for early childhood education and care (ECEC) services in providing flexible arrangements for families and local communities.
Early Childhood Australia
core  

Low-Complexity Multiple-Component Turbo Decoding Aided Hybrid ARQ

, 2011
Previous research has focused on improving the throughput of Hybrid Automatic Repeat reQuest (HARQ) schemes. However, since turbo codes have been introduced into HARQ schemes, their complexity has increased owing to the iterative Bahl, Cocke, Jelinek and
Chen, Hong, Hanzo, Lajos, Maunder, Robert G.   +2 more
core   +1 more source