Results 141 to 150 of about 648,849 (327)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Early universe in quantum gravity

open access: yesJournal of High Energy Physics
We present a new picture of the early universe in finite nonlocal quantum gravity, which is Weyl invariant at the classical and quantum levels. The high-energy regime of the theory consists of two phases, a Weyl invariant trans-Planckian phase and a post-
Leonardo Modesto, Gianluca Calcagni
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Walls, bubbles and doom — the cosmology of HEFT

open access: yesJournal of High Energy Physics
As experiment charts new territory at the electroweak scale, the enterprise to characterise all possible theories becomes all the more necessary. In the absence of new particles, this ambitious enterprise is attainable and has led to the Higgs Effective ...
R. Alonso   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Neutrino zeromodes on electroweak strings in light of topological insulators

open access: yesJournal of High Energy Physics
We examine neutrino zeromode solutions on the electroweak Z-string and their effect on the stability of the string in the standard model and its extensions.
Minoru Eto   +4 more
doaj   +1 more source

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