Results 51 to 60 of about 647,754 (283)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Creation of an inflationary universe out of a black hole

Physics Letters B, 2018
We discuss a two-step mechanism to create a new inflationary domain beyond a wormhole throat which is created by a phase transition around an evaporating black hole.
Naritaka Oshita, Jun'ichi Yokoyama
doaj   +1 more source

Black Holes in the Early Universe

, 2012
The existence of massive black holes was postulated in the sixties, when the first quasars were discovered. In the late nineties their reality was proven beyond doubt, in the Milky way and a handful nearby galaxies.
Alatalo K, Alcock C, Alexander D M, Assef R J, Barth A J, Begelman M C, Begelman M C, Bellovary J, Bellovary J M, Bennert V N, Bower R G, Bromley B C, Bromm V, Bundy K, Burkert A, Ciotti L, Clark P C, Couchman H M P, Cowie L L, Davies M B, Davies R I, Davies R I, Davies R I, Debuhr J, Devecchi B, Di Matteo T, Fan X, Ferrarese L, Gallo E, Gebhardt K, Glikman E, Graham A W, Greene J E, Greif T, Gültekin K, Haiman Z, Hawking S, Heger A, Häring N, Jeon M, Jillian Bellovary, Kelly B C, Khlopov M Y, Kim J h, Lauer T R, Levine R, Madau P, Magorrian J, Marconi A, Marta Volonteri, McCarthy I G, Merritt D, Miller B, Milosavljević M, Mullaney J R Daddi E Béthermin M Elbaz D Juneau S Pannella M Sargent M T Alexander D M Hickox R C, Murray N, Müller-Sánchez F, Oh S P, Omukai K, Park K, Peng C Y, Ricotti M, Sadoun R Colin J, Schawinski K, Schawinski K, Seth A, Silk J, Silk J, Storchi-Bergmann T, Tremaine S, Tremonti C A, Treu T, Vestergaard M, Volonteri M, Volonteri M, Wild V, Willott C J, Willott C J, Woo J H, Yan R, Zel'Dovich Y B   +80 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Metastable Supersymmetry Breaking In A Cooling Universe [PDF]

, 2007
I put metastable supersymmetry breaking in a cosmological context. I argue that under reasonable assumptions, the cooling down early Universe favors metastable SUSY-breaking vacua over the stable supersymmetric vacua. To illustrate the general argument I
Kaplunovsky, V. S.
core   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Dark matter and baryon-number generation in quintessential inflation via hierarchical right-handed neutrinos

Physics Letters B, 2019
Incorporating three generations of right-handed Majorana neutrinos to quintessential inflation, we construct a model which simultaneously explains inflation, dark energy, dark matter and baryogenesis.
Soichiro Hashiba, Jun'ichi Yokoyama
doaj   +1 more source

The supercooling window at weak and strong coupling

Journal of High Energy Physics, 2023
Supercooled first order phase transitions are typical of theories where conformal symmetry is predominantly spontaneously broken. In these theories the fate of the flat scalar direction is highly sensitive to the size and the scaling dimension of the ...
Noam Levi, Toby Opferkuch, Diego Redigolo   +2 more
doaj   +1 more source

Axions in the early universe

SciPost Physics Proceedings, 2023
The Peccei-Quinn solution to the strong CP problem provides a motivated framework rich in cosmological consequence. Thermal axion production is unavoidable if there is a thermal bath at early times.
Francesco D'Eramo
doaj   +1 more source

Cosmology of the Very Early Universe

, 2010
In these lectures I focus on early universe models which can explain the currently observed structure on large scales. I begin with a survey of inflationary cosmology, the current paradigm for understanding the origin of the universe as we observe it ...
Brandenberger, Robert H.
core   +1 more source