Results 31 to 40 of about 2,154 (233)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Bubble friction in symmetry-restoring transitions

Journal of High Energy Physics
In standard (symmetry-breaking) first-order phase transitions, the frictional pressure on expanding bubble walls can be dominated by transition radiation — the emission of a gauge boson with phase-dependent masses as particles present in the thermal ...
Andrew J. Long, Bibhushan Shakya, Julia Anabell Ziegler   +2 more
doaj   +1 more source

Bubble nucleation and quantum initial conditions in classical statistical simulations

Journal of High Energy Physics, 2022
Classical-statistical lattice simulations provide a useful approximation to out-of-equilibrium quantum field theory, but only for systems exhibiting large occupation numbers, and only for phenomena that are not intrinsically quantum mechanical in nature.
Anders Tranberg, Gerhard Ungersbäck
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Type-III seesaw in non-holomorphic modular symmetry and leptogenesis

Journal of High Energy Physics
Recently, Qu and Ding, have proposed a formalism where modular invariance is extended to non-supersymmetric scenario considering Yukawa couplings as non-holomorphic functions of modules field τ. Adopting this formalism in this work, we propose a Type-III
Priya, Labh Singh, B. C. Chauhan, Surender Verma   +3 more
doaj   +1 more source

QCD equation of state and dark matter

, 2012
The QCD equation of state is not often discussed in cosmology. However, the relic density of weakly interacting massive particles (WIMPs) depends on the entropy and the expansion rate of the Universe when they freeze out, at a temperature in the range ...
Philipsen, Owe, Hindmarsh, Mark, MARK HINDMARSH, OWE PHILIPSEN   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Bounds on the bubble wall velocity

Journal of High Energy Physics
Determining the bubble wall velocity in first-order phase transitions is a challenging task, requiring the solution of (coupled) equations of motion for the scalar field and Boltzmann equations for the particles in the plasma.
Wen-Yuan Ai, Benoit Laurent, Jorinde van de Vis   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Particle shells from relativistic bubble walls

Journal of High Energy Physics
Relativistic bubble walls from cosmological phase transitions (PT) necessarily accumulate expanding shells of particles. We systematically characterize shell properties, and identify and calculate the processes that prevent them from free streaming ...
Iason Baldes, Maximilian Dichtl, Yann Gouttenoire, Filippo Sala   +3 more
doaj   +1 more source