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Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

Detection of Early-Universe Gravitational Wave Signatures and Fundamental Physics [PDF]

, 2022
International audienceDetection of a gravitational-wave signal of non-astrophysical origin would be a landmark discovery, potentially providing a significant clue to some of our most basic, big-picture scientific questions about the Universe.
Siemens, Xavier +52 more
core +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens +2 more
wiley +1 more source

Type-III seesaw in non-holomorphic modular symmetry and leptogenesis

Journal of High Energy Physics
Recently, Qu and Ding, have proposed a formalism where modular invariance is extended to non-supersymmetric scenario considering Yukawa couplings as non-holomorphic functions of modules field τ. Adopting this formalism in this work, we propose a Type-III
Priya +3 more
doaj +1 more source

Inflection-point inflation and dark matter redux

Journal of High Energy Physics, 2022
We investigate for viable models of inflation that can successfully produce dark matter (DM) from inflaton decay process, satisfying all the constraints from Cosmic Microwave Background (CMB) and from some other observations.
Anish Ghoshal +4 more
doaj +1 more source

The CosmoVerse White Paper: Addressing observational tensions in cosmology with systematics and fundamental physics [PDF]

Physics of the Dark Universe
The standard model of cosmology has provided a good phenomenological description of a wide range of observations both at astrophysical and cosmological scales for several decades. This concordance model is constructed by a universal cosmological constant
E. Di Valentino +499 more
semanticscholar +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source

Review of particle physics

, 2004
This biennial Review summarizes much of Particle Physics. Using data from previous editions, plus 1726 new measurements from 512 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons.
Particle Data Group, Particle Data Grp
core +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source

Cosmoparticle Physics of Dark Universe

, 2022
International audienceThe physics of the dark Universe goes beyond the standard model (BSM) of fundamental interactions. The now-standard cosmology involves inflation, baryosynthesis and dark matter/energy corresponding to BSM physics.
Maxim Khlopov, Khlopov, Maxim
core +1 more source

physics
phase transitions in the early universe
particle nature of dark matter

axions and alps
baryo-and leptogenesis