Results 111 to 120 of about 6,266,241 (291)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Seismic Early Warning Systems: Procedure for automated decision making [PDF]

, 2006
Le grandi perdite economiche e sociali causate dal verificarsi di eventi sismici hanno incentivato, negli ultimi decenni, gli studi sul rischio sismico con l’obiettivo di formulare delle strategie per la mitigazione delle conseguenze di tali eventi.
Grasso, Veronica Francesca
core   +1 more source

A Hybrid Intelligent Early Warning System for Predicting Economic Crises: The Case of China [PDF]

This paper combines artificial neural networks (ANN), fuzzy optimization and time-series econometric models in one unified framework to form a hybrid intelligent early warning system (EWS) for predicting economic crises.
He, Xingxing, Su, Dongwei
core  

Maternal Early Warning Scores (MEWS) [PDF]

, 2018
According to Mothers and Babies: Reducing Risk through Audits and Confidential Enquiries in the UK (MBRRACE-UK) report 2016, maternal mortality rate is 8.5 per 100,000 maternities.
Nair, Shrijit, Dockrell, Lucy, Mac Colgain, Siaghal   +2 more
core   +1 more source

Modified early warning score system.

, 2019
Modified early warning score system.
Eveline Mestrom (6680663), Melissa van de Steeg (6680669), Erik Korsten (6680684), Rick Bezemer (6680678), R. Arthur Bouwman (6680681), Louis Atallah (6680675), Ashley De Bie (6680666), Merel Driessen (6680672)   +7 more
core   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Examining the feasiblity of informal settlement flood early warning systems : focus on the urban flood-risk experience of Kosovo and Masiphumelele residents, Cape Town South Africa [PDF]

, 2011
Includes bibliographical references (leaves 107-117).This thesis examines the feasibility of applying people-centred approaches to flood early warning systems (EWS) in informal settlements in the City of Cape Town, particularly, through the experiences ...
Solomon, F J
core   +1 more source

Exploring the potential impact of adding upper limit single trigger MET thresholds to a paediatric early warning scoring tool at a tertiary children's hospital: a retrospective review

Frontiers in Pediatrics
ObjectiveThis study aims to determine the impact of incorporating upper threshold vital sign triggers into the digital Children's Early Warning Tool (CEWT) on the number of medical emergency team (MET) alerts.MethodsDe-identified vital set data from the ...
Shawn Steckle, Casey Fowler, Victoria Campbell   +2 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source