Results 91 to 100 of about 55,077 (305)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Performance of the Emergency Department-Paediatric Early Warning Score. [PDF]

Performance of the Emergency Department-Paediatric Early Warning Score.
Navin P. Boeddha (3366875), Elizabeth V. Ledger (18195907), Stefan A. Unger (2851964), Effua Usuf (334925), Natanael Holband (4593013), Godfrey A. Kavishe (18195901), Kristina Keitel (4529020), Rainer Tan (5991500), Henriëtte A. Moll (9258027), Kevin H. van ‘t Kruys (18195904), Joany M. Zachariasse (3712918), Naomi Kemps (18195898), Abdoulie Faal (6757937), Fatou Secka (5327414), Amadu E. Juliana (10169717), Andrew M. Prentice (195160)   +15 more
core   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A Low-Power Simplified-MEWS Scoring device for Patient Monitoring [PDF]

, 2010
The Modified Early Warning System is a paper based system used in general wards of hospitals to monitor patients health during the duration of the patient stay.
Koushik Maharatna, Jeffrey S Reeve, Banerjee, Anindo, Reeve, Jeff, Dirk de Jager, Evangelos B Mazomenos, Maharatna, Koushik, Mazomenos, Evangelos, De Jager, Dirk, Anindo K Banerjee   +9 more
core   +1 more source

Physiological-Social Scores in Predicting Outcomes of Prehospital Internal Patients

Emergency Medicine International, 2014
The physiological-social modified early warning score system is a newly developed instrument for the identification of patients at risk. The aim of this study was to investigate the feasibility of using the physiological-social modified early warning ...
Abbasali Ebrahimian, Hesam Seyedin, Roohangiz Jamshidi-Orak, Gholamreza Masoumi   +3 more
doaj   +1 more source

Predictive powers of the Modified Early Warning Score and the National Early Warning Score in general ward patients who activated the medical emergency team.

PLoS ONE, 2020
BACKGROUND:The current early warning scores may be insufficient for medical emergency teams (METs) to use in assessing the severity and the prognosis of activated patients. We evaluated the predictive powers of the Modified Early Warning Score (MEWS) and
Jee Hwan Ahn, Youn Kyung Jung, Ju-Ry Lee, You Na Oh, Dong Kyu Oh, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Sang-Bum Hong   +8 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source