Results 71 to 80 of about 6,266,241 (291)

Adjusting Early Warning Score by clinical assessment: a study protocol for a Danish cluster-randomised, multicentre study of an Individual Early Warning Score (I-EWS)

BMJ Open, 2020
Introduction Track and trigger systems (TTSs) based on vital signs are implemented in hospitals worldwide to identify patients with clinical deterioration. TTSs may provide prognostic information but do not actively include clinical assessment, and their
Lars Simon Rasmussen, Kasper Karmark Iversen, Theis Lange, Gitte Bunkenborg, Pernille B Nielsen, Martin Schultz, Caroline Sophie Langkjaer, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Michael Dan Arvig, Christian Sahlholt Meyhoff, Morten Bestle, Bibi Hølge-Hazelton, Anne Lippert, Ove Andersen   +15 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A study to introduce National Early Warning Scores (NEWS) in care homes: Influence on decision‐making and referral processes

Nursing Open, 2022
Aim Early warning scores are commonly used in hospital settings, but little is known about their use in care homes. This study aimed to evaluate the impacts of National Early Warning Scores alongside other measures in this setting.
Philip Hodgson, Jane Greaves, Glenda Cook, Angela Fraser, Lesley Bainbridge   +4 more
doaj   +1 more source

Explicit Modeling and Visualization of Imperfect Information in the Context of Decision Support for Tsunami Early Warning in Indonesia [PDF]

, 2011
A certainty model and appropriate visualization techniques are presented which are applied in a newly developed Decision Support System (DSS) for tsunami early warning deployed in Jakarta, Indonesia.
Raape, Ulrich, Schoeckel, Thorsten, Friedemann, Monika, Sven Tessmann, Monika Friedemann, Thorsten Schoeckel, Strobl, Christian, Teßmann, Sven, Ulrich Raape, Christian Strobl   +9 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Accuracy of a pediatric early warning score in the recognition of clinical deterioration

Revista Latino-Americana de Enfermagem
Objective: to evaluate the accuracy of the version of the Brighton Pediatric Early Warning Score translated and adapted for the Brazilian context, in the recognition of clinical deterioration.
Juliana de Oliveira Freitas Miranda, Climene Laura de Camargo, Carlito Lopes Nascimento Sobrinho, Daniel Sales Portela, Alan Monaghan   +4 more
doaj   +1 more source

The utility of the Rapid Emergency Medicine Score (REMS) compared with three other early warning scores in predicting in-hospital mortality among COVID-19 patients in the emergency department: a multicenter validation study

BMC Emergency Medicine, 2023
Background Many early warning scores (EWSs) have been validated to prognosticate adverse outcomes of COVID-19 in the Emergency Department (ED), including the quick Sequential Organ Failure Assessment (qSOFA), the Modified Early Warning Score (MEWS), and ...
Onlak Ruangsomboon, Nutthida Phanprasert, Supawich Jirathanavichai, Chanokporn Puchongmart, Phetsinee Boonmee, Netiporn Thirawattanasoot, Thawonrat Dorongthom, Nattakarn praphruetkit, Apichaya Monsomboon   +8 more
doaj   +1 more source

Malaria epidemic early warning and detection in African highlands. [PDF]

, 2004
Malaria epidemics have long been known to recur in the African highlands. Efforts to develop systems of early warning and detection for epidemics are outlined here with special emphasis on the Highland Malaria Project (HIMAL).
de Vlas, SJ, de Vlas, Sake, Cox, J, Ochola, Samuel, Beard, B, Langi, Peter, Cox, Jonathan, Langi, P, Hay, Simon I, Abeku, TA, Beard, Brian, Ochola, S, Hay, SI, Abeku, Tarekegn A, Hay, Simon, de Vlas, Sake J   +15 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source