Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The development, validation and testing of a vital signs monitoring tool for early identification of deterioration in adult surgical patients [PDF]
, 2011 Patients often exhibit premonitory abnormalities in vital signs before an adverse clinical outcome. Patient survival may depend on the decisions of nurses to call for assistance.
Kyriacos, Una
core
Perbandingan Skoring Triage Early Warning Score (Trews), National Early Warning Score (News), Rapid Emergency Medicine Score (Rems), Dan Modified Early Warning Score (Mews) Dalam Memprediksi Tingkat Kematian Pasien Trauma Di Igd Rumah Sakit Dr. Saiful Anwar Malang [PDF]
, 2021 Pasien dengan kondisi kritis yang datang ke IGD seringkali menunjukkan tanda-tanda penurunan kondisi klinis yang jelas dan 80% dari tanda tersebut dapat dikenali lebih awal dalam 24 jam sebelum kondisi pasien semakin memburuk.
Rusli, Khairina Nurhafizah Dian Milenia Akbar
core
View Score: An early warning score to detect possible complications among COVID-19 patients
Journal of Family Medicine and Primary Care, 2023 Introduction: Understanding pulmonary function at various phases after coronavirus disease 2019 (COVID-19) infection is critical for determining the exact pathophysiological mechanism of COVID-19.
Meenakshi Bhakare +7 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Using an Early Warning Score for Nurse Shift Patient Handover: Before-and-after Study
Asian Nursing Research, 2022 Purpose: This study aimed to examine the impact of using an early warning score for shift patient handover on nurse and patient outcomes. Methods: A before-and-after study was conducted with nurses and patients in three general wards in a tertiary ...
Jee-In Hwang, Sung Wan Kim
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Prognostics Accuracy of Early Warning Score Screening in Patients with COVID-19: A Literature Review [PDF]
, 2022 The accuracy of an early warning score (EWS) in early identification of a patient’s condition can help healthcare workers to promptly and appropriately identify therapy for the patient; it is also used to determine which patients will go to the emergency
Wahyuningsih, Indri +3 more
core +2 more sources
Archives of Trauma Research, 2021 Background and Objectives: Physiological scoring systems could potentially aid emergency department (ED) trauma triage, and allowed clinicians to focus on treating the most severe patients first.
Farhad Heydari +5 more
doaj +1 more source