Results 181 to 190 of about 54,498 (352)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Pediatric early warning score and unplanned readmission with influenza at emergency observation room. [PDF]

Front Pediatr
Xu W, Liu A, Xu W, Zheng Q, Li L, Liu Y, Lei X, Kang L, Dong W.   +8 more
europepmc   +1 more source

Research on the Construction and Application of Communication Protocols for the Transfer of Critically Ill Cancer Patients in ICU under the Background of MEWS Early Warning Score [PDF]

Yanyu Chen, Qiongyao Guan, Wenting Zhang, Xiaohua Ren, Xiangping Ma, Shiyao Yang, Yuan‐Han Yang   +6 more
openalex   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Validation and performance of a geriatric early warning score (GEWS) versus the national early warning score (NEWS) in predicting clinical deterioration in frail older patients. [PDF]

Eur Geriatr Med
Baeyens H, Haegdorens F, Martens S, Abeele MEV, Wallaert S, Van Den Noortgate N, Brys ADH.   +6 more
europepmc   +1 more source

Why the C-statistic is not informative to evaluate early warning scores and what metrics to use [PDF]

, 2015
Santiago Romero‐Brufau, Jeanne M. Huddleston, Gabriel J. Escobar, Mark Liebow   +3 more
openalex   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Performance of the Dutch Pediatric Early Warning Score: a nationwide study in academic, large teaching and general hospital contexts, using real-world data. [PDF]

BMJ Paediatr Open
Stevens J, de Groot J, Hoogervorst-Schilp J, Willemsen MA, Fuijkschot J.   +4 more
europepmc   +1 more source

PERSEPSI PERAWAT TERHADAP PENERAPAN EARLY WARNING SCORE (EWS) DIRSUD BANYUMAS

, 2020
Atika Dhiah Anggraeni, Destiya Dwi Pangestika   +1 more
openalex   +1 more source