Results 31 to 40 of about 3,391,934 (334)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Elementary School Children's Understanding of Experimental Error [PDF]
, 2007 Provides pedagogical insight concerning the skill of experimental error The resource being annotated is: http://www.dlese.org/dds/catalog_DLESE-000-000-008-659 ...
Lamont-Doherty Earth Observatory, Columbia University
core
Prevalence of Earth-size planets orbiting Sun-like stars [PDF]
, 2013 Determining whether Earth-like planets are common or rare looms as a touchstone in the question of life in the universe. We searched for Earth-size planets that cross in front of their host stars by examining the brightness measurements of 42,000 stars ...
Howard, Andrew W. +2 more
core +4 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Optical Mineralogy in a Modern Earth Sciences Curriculum [PDF]
, 2007 Provides pedagogical insight concerning the skill of studying minerals The resource being annotated is: http://www.dlese.org/dds/catalog_SERC-NAGT-000-000-000-651 ...
Lamont-Doherty Earth Observatory, Columbia University
core
WHAT ON EARTH IS GOING WITH THE EARTH?!
, 2023 This article discusses the consequences of global warming and climate change mainly concentrating on water shortage which brings major health, social and geopolitical problems all around the world. It stresses what some measures need to be taken at least to avoid these problems occurring at a larger scale.
openaire +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The Development of Student Conceptions of the Earth-Sun Relationship in an Inquiry-Based Curriculum [PDF]
, 2007 Provides pedagogical insight concerning learners' pre-conceptions and misconceptions about the earth's rotation and the seasons The resource being annotated is: http://www.dlese.org/dds/catalog_SERC-NAGT-000-000-000-644 ...
Lamont-Doherty Earth Observatory, Columbia University
core
Geotomography with solar and supernova neutrinos [PDF]
, 2005 We show how by studying the Earth matter effect on oscillations of solar and supernova neutrinos inside the Earth one can in principle reconstruct the electron number density profile of the Earth. A direct inversion of the oscillation problem is possible
A. B. Borisov +23 more
core +3 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source