Results 181 to 190 of about 158,991 (313)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Training-free AI for earth observation change detection using physics aware neuromorphic networks. [PDF]

Sci Rep
Smith S, Purcell C, Kuncic Z.
europepmc   +1 more source

Detailed urban roughness parametrization for anthropogenic heat flux estimation using earth observation data. [PDF]

Heliyon, 2023
Bhatt MM, Gupta K, Danodia A, Chakroborty SD, Patel NR.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

An earth observation and explainable machine learning approach for determining the drivers of invasive species - a water hyacinth case study. [PDF]

Environ Monit Assess
Singh G, Rosman B, Byrne MJ, Reynolds C.
europepmc   +1 more source

Predicting Continental Scale Malaria With Land Surface Water Predictors Based on Malaria Dispersal Mechanisms and High-Resolution Earth Observation Data. [PDF]

Geohealth, 2023
Kalthof MWML, Gravey M, Wijnands F, Karssenberg D.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Federated and reusable processing of Earth observation data. [PDF]

Sci Data
Mohr M, Pebesma E, Dries J, Lippens S, Janssen B, Thiex D, Milcinski G, Schumacher B, Briese C, Claus M, Jacob A, Sacramento P, Griffiths P.   +12 more
europepmc   +1 more source

Corrigendum to "Detailed urban roughness parametrization for anthropogenic heat flux estimation using earth observation data" [Heliyon 9(7) (July 2023) e18361]. [PDF]

Heliyon, 2023
Bhatt MM, Gupta K, Danodia A, Chakroborty SD, Patel NR.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source