Results 71 to 80 of about 1,046,553 (302)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The observation of Extensive Air Showers from an Earth-Orbiting Satellite

, 2011
In this paper we review the main issues that are relevant for the detection of Extensive Air Showers (EAS) from space. EAS are produced by the interaction of Ultra-High Energy Cosmic Particles (UHECP) with the atmosphere and can be observed from an ...
Pallavicini, M., Pesce, R., Petrolini, A., Thea, A.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Few-Shot Learning for Crop Mapping from Satellite Image Time Series

Remote Sensing
Recently, deep learning methods have achieved promising crop mapping results. Yet, their classification performance is constrained by the scarcity of labeled samples.
Sina Mohammadi, Mariana Belgiu, Alfred Stein   +2 more
doaj   +1 more source

Fermi Large Area Telescope Observations of the Cosmic-Ray Induced gamma-ray Emission of the Earth's Atmosphere

, 2009
We report on measurements of the cosmic-ray induced gamma-ray emission of Earth's atmosphere by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope. The LAT has observed the Earth during its commissioning phase and with a dedicated Earth-
Abdo, A. A., Ackermann, M., Ajello, M., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Baughman, B. M., Bechtol, K., Bellazzini, R., Bernji, B., Bloom, E. D., Bonamente, E., Borgland, A. W., Bouvier, A., Bregeon, J., Brez, A., Brigida, M., Bruel, P., Buehler, R., Burnett, T. H., Buson, S., Caliandro, G. A., Cameron, R. A., Caraveo, P. A., Casandjian, J. M., Cecchi, C., Celik, Ö., Charles, E., Chekthman, A., Chiang, J., Ciprini, S., Claus, R., Cohen-Tanugi, J., Conrad, J., de Palma, F., Digel, S. W., do Couto e Silva, E., Drell, P. S., Dubois, R., Dumora, D., Farnier, C., Favuzzi, C., Fegan, S. J., Focke, W. B., Fortin, P., Frailis, M., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gehrels, N., Germani, S., Giebels, B., Giglietto, N., Giordano, F., Glanzman, T., Godfrey, G., Grenier, I. A., Grondin, M.-H., Grove, J. E., Guillemot, L., Guiriec, S., Hays, E., Horan, D., Hughes, R. E., Johannesson, G., Johnson, A. S., Johnson, T. J., Johnson, W. N., Kamae, T., Katagiri, H., Kataoka, J., Kawai, N., Kerr, M., Knödlseder, J., Kuss, M., Lande, J., Latronico, L., Lemoine-Goumard, M., Longo, F., Loparco, F., Lott, B., Lovelette, M. N., Lubrano, P., Makeev, A., Mazziotta, M. N., McEnery, J. E., Meurer, C., Michelson, P. F., Mitthumsiri, W., Mizuno, T., Monte, C., Monzani, M. E., Morselli, A., Moskalenko, I. V., Murgia, S., Nolan, P. L., Norris, J. P., Nuss, E., Ohsugi, T., Okumura, A., Omodei, N., Orlando, E., Ormes, J. F., Paneque, D., Panetta, J. H., Parent, D., Pelassa, V., Pepe, M., Pesce-Rollins, M., Piron, F., Porter, T. A., Raino, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Reposeur, T., Rochester, L. S., Rodriguez, A. Y., Roth, M., Sadrozinski, H. F.-W., Sander, A., Saz Parkinson, P. M., Sgro, C., Share, G. H., Siskind, E. J., Smith, D. A., Smith, P. D., Spandre, G., Spinelli, P., Strickman, M. S., Suson, D. J., Takahashi, H., Tanaka, T., Thayer, J. B., Thayer, J. G., Thompson, D. J., Tibaldo, L., Torres, D. F., Tosti, G., Tramacere, A., Uchiyama, Y., Usher, T. L., Vasileiou, V., Vilchez, N., Vitale, V., Waite, A. P., Wang, P., Winer, B. L., Wood, K. S., Ylinen, T., Ziegler, M.   +154 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Supernova neutrinos: production, propagation and oscillations

, 2004
I shall review some of the recent results concerning the astrophysics of a core collapse supernova (SN) and neutrino oscillations. Neutrinos play an important role in the SN explosion, and they also carry most of the energy of the collapse.
Amol Dighe, Ando, Beacom, Beacom, Bethe, Bueno, Buras, Buras, Dighe, Dighe, Dighe, Dighe, Dighe, Fogli, Gil-Botella, Halzen, Keil, Lunardini, Lunardini, Lunardini, Mezzacappa, Raffelt, Raffelt, Raffelt, Schirato, Scholberg, Takahashi, Takahashi, Tomas, Tomas, Totani   +30 more
core   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source