Results 101 to 110 of about 33,136,764 (335)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Inside this issue: --- News from the Earth Science Staff --- Profile: Ken De Nault --- Earth Science Majors --- Sigma Gamma Epsilon - Gamma Sigma Chapter --- Gifts to the Department of Earth Science --- 1996 Scholarships and Award Recipients --- Student ...
Department of Earth Science, University of Northern Iowa.
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Inside this issue: --- Earth Science Staff Activities --- Faculty Research, Publications, and Recognition --- Profile: Wayne Anderson --- PRISMS Helps Physic Students See --- UNI Meteorology Students Chase Tornadoes in Des Moines --- Technology Takes
Department of Earth Science, University of Northern Iowa.
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Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Inside this issue: --- Faculty Achievements and Activities --- 1998 Earth Science Graduates --- Student Research Presentations --- Sigma Gamma Epsilon - Gamma Sigma Chapter --- Earth Science Majors --- Observatory: Room with a Stellar View --- Gifts to ...
Department of Earth Science, University of Northern Iowa.
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Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Half-title page: Teaching earth science in the junior high school
This teaching guide consists of unit plans for the various divisions of earth science. The plans are, as the title suggests, a guide for the teacher and could be used In conjunction with any number of earth science textbooks; the writer has elected to ...
Regnier, Patricia, 1943-
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