Results 111 to 120 of about 33,136,764 (335)

Earth News, v28, Fall 2004 [PDF]

, 2004
Inside this issue: --- Earth Science Staff Activities --- Earth Science Majors --- Student Internships --- From Ocean to Ice: GSI 2004 Spring Field Trip Highlights --- National Earth Science Week Quarry Open House --- Sigma Gamma Epsilon - Gamma Sigma ...
Department of Earth Science, University of Northern Iowa.
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

大数据时代的地球科学知识图谱研究现状与展望

Dizhen xuebao
地球科学是一门数据密集型学科，而知识图谱则被认为是充分利用和发挥地球科学领域庞大数据的一种有效方式。相对于通用大模型技术的发展，知识图谱能提供更为准确的知识，增强生成式大模型结果的智能性和可靠性。本文首先阐释了知识图谱的相关概念和构建方法；然后，对在科学领域广泛应用的顶层本体基本形式化本体模型进行了详细介绍，简单总结了地球科学领域已经建成的知识图谱，并着重论述了地球科学领域的地质学核心本体和地质科学本体，以及两者的异同；最后，介绍了与地球科学知识图谱构建相关的深时数字地球计划等国际地学数据科学计划 ...
Fenggui Niu, Bei Zhang, Shi Chen
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Earth News, v29, Fall 2005 [PDF]

, 2005
Inside this issue: --- Earth Science Staff Activities --- A T. rex Named Sue --- Earth Science Seminar Series --- From Ocean to Ice: GSI 2004 Spring Field Trip Highlights --- Physical Geology Professor Keeps Passion for Teaching, Researching --- Earth ...
Department of Earth Science, University of Northern Iowa.
core   +1 more source

Visualization analysis of ambient seismic noise research

Frontiers in Earth Science
In recent years, ambient seismic noise has gained considerable attention in seismology due to its potential to advance understanding of Earth’s subsurface dynamics and monitor anthropogenic activities.
Lihui Wu, Lihui Wu, Jinling Li, Sarina Bao, Qianbin Gong   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source