Results 131 to 140 of about 33,136,764 (335)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Earth News, v27, Fall 2003 [PDF]

, 2003
Inside this issue: --- Earth Science Staff Activities --- Earth Science Majors --- 2002 Earth Science Graduates --- Student Internships --- Student Research Presentations --- STORM Project Team --- Earth Science Seminar Series --- Sigma Gamma Epsilon ...
Department of Earth Science, University of Northern Iowa.
core   +1 more source

The earth science and nonlinear science

Chinese Science Bulletin, 1998
Liu, Shida, Liu, Shikuo
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Earth News, v26, Fall 2002 [PDF]

, 2002
Inside this issue: --- Earth Science Staff Activities --- STORM Curriculum Development Update --- Earth Science Majors --- Earth Science Student Assistants --- Earth Science Seminar Series --- Sigma Gamma Epsilon - Gamma Sigma Chapter --- Summer 2002 ...
Department of Earth Science, University of Northern Iowa.
core   +1 more source

Factors affecting upper secondary school students' earth science academic achievement: A structural equation modeling approach

Acta Psychologica
To understand how to enhance upper secondary school students' academic achievement in Earth sciences, this study used structural equation modeling to investigate the key factors and mechanisms affecting their academic achievement.
Yonghui Ni, Liyun Lu, Guiping Liu, Huimin Wei, Yu Zhang, Chenjing Lu, Pengtao Zhang, Zizi Wei, Hongyu Qian, Yanhua Xu   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Advancing Water Security and National Preparedness Through Earth Science Observations and the Earth Science Workforce

Earth and Space Science
U.S. civil spaceborne assets represent the forefront of engineering innovation across remote sensing domains such as gravimetry, thermal radiometry, imaging spectroscopy, light detection and ranging (LiDAR), and synthetic aperture radar (SAR).
Christine M. Lee, Brandi Downs, Rashmi Shah, Erin L. Hestir, Susan Owen, David Schimel, J. T. Reager, Anthony Nguy‐Robertson, John D. Bolten, Thomas M. Parris, Charles Iceland, John Eylander, Africa Flores‐Anderson, Ryan Perkl, Venkataraman Lakshmi   +14 more
doaj   +1 more source

A multi-hazards earth science perspective on the COVID-19 pandemic: the potential for concurrent and cascading crises. [PDF]

Environ Syst Decis, 2020
Quigley MC, Attanayake J, King A, Prideaux F.   +3 more
europepmc   +1 more source