Results 51 to 60 of about 258,278 (245)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Reimagining Geoscience Education for Sustainability

Earth Science, Systems and Society
Geoscience is crucial for addressing sustainability challenges related to climate change, the energy transition, water resources management, and natural hazards.
Ellen P. Metzger
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Triple rigor, Braiding Sweetgrass, and Food Dignity lessons for eighth grade earth science and beyond

Journal of Agriculture, Food Systems, and Community Development
Christine Porter called for three forms of rigor—emotional, ethical, and epistemological—to be applied to academic research about sustainable food systems.
Katharine Bradley
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improving EMS access: Strategic helicopter infrastructure and 3D virtual training for enhanced ground-air ambulance coordination

iScience
Summary: This study aimed to develop a methodology to strengthen coordination between ground ambulances and helicopter emergency medical services (EMS) for rapid patient transport.
Soyoung Jung, Xiao Qin, Sooyeon Lim
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Google Earth as a Tool for Supporting Geospatial Thinking

Land
In landscape planning and design, geospatial technologies (GSTs) are used to aid in visualizing and interpreting geographic environments, identifying geospatial patterns, and making decisions around information based on maps and geospatial information ...
Allison J. Jaeger
doaj   +1 more source

The EPOS multi-disciplinary Data Portal for integrated access to solid Earth science datasets. [PDF]

Sci Data, 2023
Bailo D, Paciello R, Michalek J, Cocco M, Freda C, Jeffery K, Atakan K.   +6 more
europepmc   +1 more source