Results 71 to 80 of about 1,830,401 (244)
Quantitative modelling of the human–Earth System a new kind of science?
, 2013 The five grand challenges set out for Earth System Science by the International Council for Science in 2010 require a true fusion of social science, economics and natural science—a fusion that has not yet been achieved.
Brede, Markus +2 more
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Our Mission to Planet Earth: A Guide to Teaching Earth System Science [PDF]
, 1994 This teaching guide provides hands-on activities and information related to studying the Earth system. Its primary goal is for children to become familiar with the concept of cycles and to learn that some human activities can cause changes in their ...
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Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
A multi-hazards earth science perspective on the COVID-19 pandemic: the potential for concurrent and cascading crises. [PDF]
Environ Syst Decis, 2020 Quigley MC +3 more
europepmc +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Earth system data record from DSCOVR EPIC observations: product description and analyses [PDF]
, 2018 The NASA's Earth Polychromatic Imaging Camera (EPIC) onboard NOAA's Deep Space Climate Observatory (DSCOVR) mission was launched on February 11, 2015 to the Sun-Earth Lagrangian L1 point where it began to collect radiance data of the entire sunlit Earth ...
Knyazikhin, Yuri +5 more
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
NASA Earth and Space Science Explorers Poster [PDF]
, 2007 This poster features several of the NASA Earth and Space Science Explorers, plus suggestions for using the series in the classroom. The series of online articles features NASA explorers, young and old, with many backgrounds and interests.
IGES
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