Results 121 to 130 of about 1,466,569 (295)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Monitoring flood risk evolution: A systematic review

open access: yesiScience
Summary: Land-use change, climate change, human interventions, and socio-economic developments influence the evolution of the risk components hazard, exposure, and vulnerability, and consequently of flood risk.
Nele Rindsfüser   +2 more
doaj   +1 more source

Relationship between science and technology in the New Zealand curriculum [PDF]

open access: yes, 1997
New Zealand underwent major curriculum reforms in the early1990s. These reforms were determined by the New Zealand Curriculum Framework (Ministry of Education 1993), which provides an overarching framework for the development of curricula in New Zealand ...
Jones, Alister
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Electrokinetics in Earth Sciences

open access: yesInternational Journal of Geophysics, 2013
Laurence Jouniaux, Tsuneo Ishido
doaj   +1 more source

The association of climate-induced stressors on risk of negative sentiment: An analysis from 462 million geotagged tweets in Europe

open access: yesiScience
Summary: This study examines how climate-induced health risks influence negative sentiments on European social tweets from 2015 to 2022. Analyzing over 400 million tweets using NLP tools (NLTK, LIWC22) and spatial-temporal aggregation at the NUTS2 weekly
Tareq Al-Ahdal   +10 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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