Results 121 to 130 of about 251,588 (268)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
William John Burchell: The multi-skilled polymath
South African Journal of Science, 2012 On the bicentenary of William John Burchell's sojourn and journey in southern Africa, we review his contribution to science in the region. In November 1810, Burchell arrived in Cape Town and, in mid-1811, he set off on a 4-year, 7000-km journey of ...
Roger Stewart, Brian Warner
doaj +4 more sources
Hungarian Geographical Bulletin, 2013 Today flash floods are one of the most significant extreme weather-related natural hazards. Due to the global climate change and altered land use, intense runoff and flash floods may exert catastrophic hydrologic impacts on developed areas.
Péter Hegedűs +4 more
doaj
Open Access Journals / Institutional Repositories [PDF]
, 2008 Düpow, Heidi +2 more
core +1 more source
Rotational Spectral Unmixing of Exoplanets: Degeneracies between Surface Colors and Geography
, 2017 Unmixing the disk-integrated spectra of exoplanets provides hints about heterogeneous surfaces that we cannot directly resolve in the foreseeable future.
Cowan, Nicolas B. +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Re-establishing Justice as a Pillar of Ecological Economics Through Feminist [PDF]
, 2018 Ecological economics has long claimed distributive justice as a central tenet, yet discussions of equity and justice have received relatively little attention over the history of the field.
Erickson, J.D. +2 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source