Results 101 to 110 of about 16,799,293 (239)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

In memoriam Andrija Bognár (1937–2019)

Hungarian Geographical Bulletin, 2019
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Dénes Lóczy
doaj  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Shaping Interconnected Geography in Central and Eastern European Academia—Key Research Challenges for the Future

Geo: Geography and Environment
Central and Eastern European geography, shaped by its entanglement of natural and social sciences, provides a distinctive lens for rethinking the unity of the discipline.
Mariusz Lamentowicz, Grzegorz Micek, Mateusz C. Strzelecki, Tomasz Wites   +3 more
doaj   +1 more source

In memoriam Attila Barczi (1964–2020)

Hungarian Geographical Bulletin, 2020
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Dénes Lóczy
doaj  

MASTERING THE FRENCH LANGUAGEIN AND BY SCHOOL DISCIPLINESLanguage practicesand the report in writing in school subjects in collegein French, history-geography, life and earth sciences and physical education and sportsComparative approach

, 2017
Cette recherche a pour objet l'étude de la contribution des disciplines, à l'évolution descollégiens dans leur maîtrise de la langue française. La position de la France dans lesévaluations PISA et les nouvelles préoccupations de l'Union Européenne en matière d'égalitédes chances amènent notre système scolaire à reconsidérer la place du langage dans ...
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Estimation of flow rate calculation errors on the example of five rapid response catchments in the Mecsek Hills

Hungarian Geographical Bulletin, 2013
Today flash floods are one of the most significant extreme weather-related natural hazards. Due to the global climate change and altered land use, intense runoff and flash floods may exert catastrophic hydrologic impacts on developed areas.
Péter Hegedűs, Szabolcs Czigány, Ervin Pirkhoffer, László Balatonyi, Levente Ronczyk   +4 more
doaj  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source