Results 81 to 90 of about 16,433 (224)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Shaping Interconnected Geography in Central and Eastern European Academia—Key Research Challenges for the Future

Geo: Geography and Environment
Central and Eastern European geography, shaped by its entanglement of natural and social sciences, provides a distinctive lens for rethinking the unity of the discipline.
Mariusz Lamentowicz, Grzegorz Micek, Mateusz C. Strzelecki, Tomasz Wites   +3 more
doaj   +1 more source

In memoriam Attila Barczi (1964–2020)

Hungarian Geographical Bulletin, 2020
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Dénes Lóczy
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

William John Burchell: The multi-skilled polymath

South African Journal of Science, 2012
On the bicentenary of William John Burchell's sojourn and journey in southern Africa, we review his contribution to science in the region. In November 1810, Burchell arrived in Cape Town and, in mid-1811, he set off on a 4-year, 7000-km journey of ...
Roger Stewart, Brian Warner
doaj   +4 more sources

Estimation of flow rate calculation errors on the example of five rapid response catchments in the Mecsek Hills

Hungarian Geographical Bulletin, 2013
Today flash floods are one of the most significant extreme weather-related natural hazards. Due to the global climate change and altered land use, intense runoff and flash floods may exert catastrophic hydrologic impacts on developed areas.
Péter Hegedűs, Szabolcs Czigány, Ervin Pirkhoffer, László Balatonyi, Levente Ronczyk   +4 more
doaj  

Table-top earthquakes; a demonstration of seismology for teachers and students that can be used to augment lessons in earth science, physics, math, social studies, geography [PDF]

Open-File Report, 1998
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source