Results 71 to 80 of about 16,799,293 (239)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of urban blue spaces on urban surface temperatures - A seasonal perspective

Scientific Reports
Assessments on the cooling potential of natural environments in urban areas has largely focussed on green spaces at very specific spatial and temporal dimensions. Less has been studied so far about the surface thermal heat mitigation effect of urban blue
Lukas Fricke, Nadja Kabisch
doaj   +1 more source

Assessing the potential of complex artificial neural networks for modelling small-scale soil erosion by water [PDF]

SOIL
Modelling soil erosion by water is essential for developing effective mitigation strategies and preventing on- and off-site damages in agricultural areas.
N. Barthel, S. Ott, B. Burkhard, B. Steinhoff-Knopp   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Prediction of Landslide Susceptibility Using Rare Events Logistic Regression (A Case-Study: Ziarat Drainage Basin, Gorgan)

علوم آب و خاک, 2018
Ziarat drainage basin, in the southern part of Gorgan city, is exposed to mass movement, especially landslide occurrence, due to geologic, geomorphologic, and anthropogenic reasons.
K. Nosrati, M. Heydari, M. Hoseinzadeh, S. Emadoddin   +3 more
doaj  

Soil Moisture Conservation through Crop Diversification and Related Ecosystem Services in a Blown-Sand Area with High Drought Hazard

Plants
Soil moisture reserves are a key factor in maintaining soil fertility and all other related ecosystem services (including carbon sequestration, soil biodiversity, and soil erosion control).
Dénes Lóczy, József Dezső, Tamás Weidinger, László Horváth, Ervin Pirkhoffer, Szabolcs Czigány   +5 more
doaj   +1 more source

Fingerprinting sub-basin spatial sediment sources in a large Iranian catchment under dry-land cultivation and rangeland farming: Combining geochemical tracers and weathering indices

Journal of Hydrology: Regional Studies, 2019
Study region: The Kamish River catchment (308 km2); a mountainous agricultural catchment under dry-land and rangeland farming located in Kermanshah province, in western Iran.
Zeinab Mohammadi Raigani, Kazem Nosrati, Adrian L. Collins   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source