Results 161 to 170 of about 250,403 (271)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Geographical barriers and multimorbidity in quilombola territories of the amazon region. [PDF]

open access: yesPLoS One
Aquino LS   +12 more
europepmc   +1 more source

Field Study for Remote Sensing: An instructor's manual [PDF]

open access: yes
The need for and value of field work (surface truthing) in the verification of image identification from high atitude infrared and multispectral space sensor images are discussed in this handbook which presents guidelines for developing instructional and
Hull, G. A., Wake, W. H.
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Atmospheric systems drive spatiotemporal divergence of dust and moisture changes across Asia over the past 130,000 years. [PDF]

open access: yesSci Adv
Li G   +35 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The billion-dollar case for sustaining palaeontology's digital databases. [PDF]

open access: yesNat Ecol Evol
Dowding EM   +21 more
europepmc   +1 more source

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