Results 51 to 60 of about 435 (263)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Advanced Diagnostic Techniques for Earthing Brush Faults Detection in Large Turbine Generators

open access: yesEnergies
Large steam turbine generators are increasingly vulnerable to damage from shaft voltages and bearing currents due to the widespread adoption of modern power electronic excitation systems and more flexible operating regimes.
Katudi Oupa Mailula, Akshay Kumar Saha
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Laboratory Setup and Exercise to Evaluate the Characteristics of Different Earthing Systems

open access: yesCurrent Directions in Biomedical Engineering
In the bachelor program Medical Engineering, we have introduced the elective course Safety of Medical Electrical Equipment Lab Exercises. One of the lab exercises deals with the topic characteristics of different earthing systems and electricity supply ...
Barchet Max, Biehl Volker
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

COMPARISON OF EARTHING TECHNIQUES FOR SINGLE LINE TO GROUND FAULT IN 11 kV DISTRIBUTION SYSTEM USING SIMULINK

open access: yesJournal of Engineering and Sustainable Development, 2019
In this paper, a new smart earthing method was proposed to reduce the current magnitude of a single line to a ground fault and thus reduce the damage caused by this fault.
Ali Abdulabbas Abdullah   +2 more
doaj  

Carbon Emission Evaluation Method and Comparison Study of Transformer Substations Using Different Data Sources

open access: yesBuildings, 2023
The construction of transformer substations in transmission lines is a systematic, technical, and complex project with the need for numerous materials and resources. Under the development of the green economy, the requirements for energy conservation and
Xigang Liu   +8 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Results of long-term field tests of protective earthing device for vessel electric systems [PDF]

open access: yesVestnik MGTU, 2015
The results of prolonged natural tests of protective neutral earthing device for controlling the fire and electrical safety of vessel electric systems have been shown.
Blaginin V.A.   +4 more
doaj  

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