Results 31 to 40 of about 6,163,874 (353)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Vestnik MGIMO-Universiteta, 2014 The study of Western countries and teaching courses on the related subjects have longstanding and established tradition at MGIMO-University. The basis of this brilliant research and teaching tradition was laid down by such academicians as E.V.
V. O. Pechatnov, E. O. Obichkina
doaj +1 more source
The East Midlands public procurement opportunities plan [PDF]
, 2009 Public sector procurement activity accounts for a significant share of economic activity. This document sets out how the East Midlands can maximize the commercial benefits of these opportunities and contribute to the delivery of public policy in the ...
East Midlands Development Agency
core
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Études Britanniques ContemporainesThis issue of Études britanniques contemporaines stems from the annual SEAC conference organised by CECILLE and the University of Lille in the autumn of 2023.
Claire Hélie
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Integrated Strategies for the Management of Wadi Flash Floods in the Middle East and North Africa (MENA) Arid Zones: The ISFF Project [PDF]
, 2021 Sameh A. Kantoush +3 more
openalex +1 more source
Cancer Biology & Therapy, 2002 Menstrual cycle activity predisposes to ovarian epithelial tumors based on numerous epidemiological studies. We showed that the hormones involved in menstrual cycle regulation modulate cell cycle activity in these tumors in an accompanying paper. We investigated whether such hormones could also influence angiogenesis, an important determinant of tumor ...
openaire +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Turcology ResearchDoğu ve Batı medeniyetleri arasında tarih boyunca çeşitli farklılıklar her zaman var olmuştur. Bu durum, birçok sosyal ve beşerî bilim dalının araştırma alanında önemli çalışmalara konu edilmiştir.
Esra Kürüm
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source