Results 41 to 50 of about 5,833,618 (304)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Türkiye’yi Doğu ve Batı Kavramları Üzerinden Konumlandırmak: Kültürel Kodlar ve Formel Jeopolitik Söylemler

open access: yesCoğrafi Bilimler Dergisi
This study focuses on how Turkey is positioned between the East and the West through discourses and narratives on the imaginaries of its changing geopolitical trajectory. Specifically, it aims to investigate how the geopolitical and cultural mentality
Belçim Öztürk, Nurettin Özgen
doaj   +1 more source

Contradicting Confrontation with Colonial Orientalism in Abdulrahman Munif’s “Ard As-Sawaad” [PDF]

open access: yesدراسات في اللغة العربيّة وآدابها, 2017
Orientalism, apart from being an attempt to introduce “the Orient”, and a manifestation of liaison between the East and the West, also has aimed to control and colonize. Therefore, Colonial Orientalism is a familiar term for the educated eastern writers,
Fatima parchekani   +2 more
doaj   +1 more source

East Midlands healthcare and bioscience sector strategy [PDF]

open access: yes, 2007
The healthcare and bioscience sector is one of four priority sectors identified in the regional economic strategy, A Flourishing Region. This document sets out a strategy for maximising the contribution of the healthcare and biosciences sector to the ...
East Midlands Development Agency
core  

Maximal subsemigroups of the semigroup of all mappings on an infinite set [PDF]

open access: yes, 2013
In this paper we classify the maximal subsemigroups of the \emph{full transformation semigroup} $\Omega^\Omega$, which consists of all mappings on the infinite set $\Omega$, containing certain subgroups of the symmetric group $\sym(\Omega)$ on $\Omega ...
East, J., Mitchell, J. D., Péresse, Y.
core   +4 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

TIME, SPACE, AND MAGICAL REALISM: SALMAN RUSHDIE’S EAST, WEST AND THE JUXTAPOSITION OF TEMPORAL AND SPATIAL LANDSCAPES [PDF]

open access: yesIncursiuni în imaginar
Although best known for his novels, Salman Rushdie has effectively managed to contrast magical or fantastical elements in his short stories. East, West is a collection of short stories in which Salman Rushdie skilfully weaves together narratives to ...
Corina Mariana Mitrulescu
doaj   +1 more source

An Introduction to the emda Knowledge Bank [PDF]

open access: yes, 2011
This document provides an introduction to the emda Knowledge Bank. It describes the nature of material included and provides a description of the role and development of ...
East Midlands Development Agency
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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