Results 41 to 50 of about 1,073,531 (266)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Artistic Role of Symbols in Ivan Gončarov's "Oblomov"
Limbaj si Context, 2019 The article deals with the aesthetic characteristics of the symbols "home", "way", "light" and also examines the artistic role of these symbols in the structure of Oblomov's image.
Vladimir Brajuc
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Critical Stages, 2018 Chinese theatre has gone through a drastic period of free development and exploration since 1980. Many new phenomena and tendencies have occurred during those years. The article is a panoramic summary of this productive and varied trajectory.
Lin Kehuan
doaj
Comparison of national identities in Ukraine and Slovakia (in search of shared and conflict perceptions and stereotypes) [PDF]
Annales Scientia Politica, 2019 The study compares identities of the Ukrainian and Slovak ethnicities; they both contribute with their respective uniqueness to Europe – in a certain sense – as a supranational community as well as to Europe consisting of differences and regional ...
Gita Geremešová
doaj
The importance of the 'Asian values' concept for modern political systems of East and Southeast Asia [PDF]
Megatrend Revija, 2020 This paper analyzes the significance of the concept of "Asian values" for modern political systems of East and Southeast Asia. Taking the theoretical basis of one of the creators of the concept of "Asian values" - Lee Kuan Yew, as a starting point, the ...
Lončar Mirela
doaj
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Cancer Biology & Therapy, 2002 Menstrual cycle activity predisposes to ovarian epithelial tumors based on numerous epidemiological studies. We showed that the hormones involved in menstrual cycle regulation modulate cell cycle activity in these tumors in an accompanying paper. We investigated whether such hormones could also influence angiogenesis, an important determinant of tumor ...
openaire +2 more sources