Results 41 to 50 of about 3,209,314 (313)
The importance of the 'Asian values' concept for modern political systems of East and Southeast Asia [PDF]
Megatrend Revija, 2020 This paper analyzes the significance of the concept of "Asian values" for modern political systems of East and Southeast Asia. Taking the theoretical basis of one of the creators of the concept of "Asian values" - Lee Kuan Yew, as a starting point, the ...
Lončar Mirela
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
East-West Center review, Vol. 3 no. 1 (June 1966)
, 1966 For more about the East-West Center, see http://www.eastwestcenter.org/Contents: A Note on the meaning of the term "Intellectual elite" in the Philippines; East-West philosophy; Science as a second culture; The function of the Tao in traditional Chinese
East-West Center Grantees' Association
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TIME, SPACE, AND MAGICAL REALISM: SALMAN RUSHDIE’S EAST, WEST AND THE JUXTAPOSITION OF TEMPORAL AND SPATIAL LANDSCAPES [PDF]
Incursiuni în imaginarAlthough best known for his novels, Salman Rushdie has effectively managed to contrast magical or fantastical elements in his short stories. East, West is a collection of short stories in which Salman Rushdie skilfully weaves together narratives to ...
Corina Mariana Mitrulescu
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Contradicting Confrontation with Colonial Orientalism in Abdulrahman Munif’s “Ard As-Sawaad” [PDF]
دراسات في اللغة العربيّة وآدابها, 2017 Orientalism, apart from being an attempt to introduce “the Orient”, and a manifestation of liaison between the East and the West, also has aimed to control and colonize. Therefore, Colonial Orientalism is a familiar term for the educated eastern writers,
Fatima parchekani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source