Results 41 to 50 of about 5,782,028 (302)

Introduction

Études Britanniques Contemporaines
This issue of Études britanniques contemporaines stems from the annual SEAC conference organised by CECILLE and the University of Lille in the autumn of 2023.
Claire Hélie
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Maximal subsemigroups of the semigroup of all mappings on an infinite set [PDF]

, 2013
In this paper we classify the maximal subsemigroups of the \emph{full transformation semigroup} $\Omega^\Omega$, which consists of all mappings on the infinite set $\Omega$, containing certain subgroups of the symmetric group $\sym(\Omega)$ on $\Omega ...
East, J., Mitchell, J. D., Péresse, Y.
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Türkiye’yi Doğu ve Batı Kavramları Üzerinden Konumlandırmak: Kültürel Kodlar ve Formel Jeopolitik Söylemler

Coğrafi Bilimler Dergisi
This study focuses on how Turkey is positioned between the East and the West through discourses and narratives on the imaginaries of its changing geopolitical trajectory. Specifically, it aims to investigate how the geopolitical and cultural mentality
Belçim Öztürk, Nurettin Özgen
doaj   +1 more source

Contradicting Confrontation with Colonial Orientalism in Abdulrahman Munif’s “Ard As-Sawaad” [PDF]

دراسات في اللغة العربيّة وآدابها, 2017
Orientalism, apart from being an attempt to introduce “the Orient”, and a manifestation of liaison between the East and the West, also has aimed to control and colonize. Therefore, Colonial Orientalism is a familiar term for the educated eastern writers,
Fatima parchekani, Farhad rajabi, Milad Darvishi   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

TIME, SPACE, AND MAGICAL REALISM: SALMAN RUSHDIE’S EAST, WEST AND THE JUXTAPOSITION OF TEMPORAL AND SPATIAL LANDSCAPES [PDF]

Incursiuni în imaginar
Although best known for his novels, Salman Rushdie has effectively managed to contrast magical or fantastical elements in his short stories. East, West is a collection of short stories in which Salman Rushdie skilfully weaves together narratives to ...
Corina Mariana Mitrulescu
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Over a decade of achievements [PDF]

, 2011
This is a corporate publication describing key achievements of the East Midlands Development Agency 1999 ...
East Midlands Development Agency, EMDA
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