Results 21 to 30 of about 591,850 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Comprehensive dataset of annotated rice panicle image from Bangladesh

Data in Brief, 2023
Bangladesh's economy is primarily driven by the agriculture sector. Rice is one of the staple food of Bangladesh. The count of panicles per unit area serves as a widely used indicator for estimating rice yield, facilitating breeding efforts, and ...
Mohammad Rifat Ahmmad Rashid, Md. Shafayat Hossain, MD Fahim, Md. Shajibul Islam, Tahzib-E-Alindo, Rizvee Hassan Prito, Md. Shahadat Anik Sheikh, Md Sawkat Ali, Mahamudul Hasan, Maheen Islam   +9 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The turnaround in internal migration between East and West Germany over the period 1991 to 2018

Demographic Research, 2020
Background: After losing a population of more than 1.2 million through migration to the West, in 2017 East Germany recorded net internal migration gains for the very first time since reunification.
Nico Stawarz, Nikola Sander, Harun Sulak, Matthias Rosenbaum-Feldbrügge   +3 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Floral and Geometrical Motives of the Pavement Mosaics in East and West. The Example of the Roman Villa of Abicada

Journal of Mosaic Research, 2012
Even if the figurative mosaics are usually the ones to catch the attention of the archeologists and the public, we cannot deny the meaning of the geometrical and the floral motives for the study of the mosaics landscape in the roman world.
Maria de Jesus DURAN KREMER
doaj  

The Council of Nicaea on baptism

In die Skriflig
The canons of the Council of Nicaea mention baptism three times: solid education into baptism is required, baptism by heretics is refuted, and baptism by schismatics is accepted.
Abraham van de Beek
doaj   +1 more source

Connecting West and East [PDF]

International Journal of Molecular Sciences, 2019
Despite their similarities, Western medicine and Eastern medicine are very different because they are built on different fundamentals. The general idea has arisen that we will benefit by connecting Western and Eastern medicine. First, both the merits as well as the limitations of both types of medicine are discussed.
Ming Zhang, Mohamed Moalin, Guido R.M.M. Haenen   +2 more
openaire   +3 more sources

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl, Marika C. Möller, Lindsay Wilson, Anne Vik, Toril Skandsen, Jonas Stenberg, CENTER‐TBI participants and investigators   +6 more
wiley   +1 more source