Results 41 to 50 of about 470,045 (312)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal   +3 more
wiley   +1 more source

Between East and West: Kazakhstan and China’s new Silk Road

open access: yesRevista CIDOB d'Afers Internacionals, 2015
This article analyses Kazakhstan’s vision of long-term development and its ambitious goals. After revising the history of the infrastructure projects in the country during the tsarist period and the Soviet era, it sets out the plans of the Kazakh ...
Ryskeldi Satke, Franco Galdini
doaj  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

open access: yesAdvanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng   +15 more
wiley   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

open access: yesAdvanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao   +7 more
wiley   +1 more source

(Why) have women left East Germany more frequently than men?

open access: yesHeidelberger Jahrbücher Online, 2018
There has been a massive internal migration from East to West Germany after German reunification in 1990. While there is a higher net emigration rate for women than for men, this is not the result of a surplus of women leaving East Germany, but a result
Johannes Stauder
doaj   +1 more source

The West versus Beijing? : determinants of the UN Human Rights Council Vote (not) to debate human rights in Xinjiang

open access: yes, 2023
For more about the East-West Center, see http://www.eastwestcenter.org/This paper addresses the factors shaping the vote of member states on the United Nations Human Rights Council (UNHRC) regarding whether to debate human rights conditions in the ...
Noland, Marcus, Hendrix, Cullen S.
core  

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

open access: yesAdvanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang   +18 more
wiley   +1 more source

Causal‐Guided Ultra‐Long‐Term Time Series Forecasting Via Anticipated Covariates

open access: yesAdvanced Science, EarlyView.
Often treated as unknown, information from the future remains underutilized.We demonstrate that in a coupled dynamical system, providing the future state of the effect enables accurate forecasting of the cause for a long timesteps. A time series forecasting paradigm that introduces anticipated covariates to represent such known future states is ...
Jintong Zhao   +4 more
wiley   +1 more source

EAST AND WEST IN THE FACE OF TECHNOLOGICAL CHANGE

open access: yesZygon, 1989
. Technological changes affect Western culture in three ways: the ratio between the lifetimes of technologies and the human lifetime is inverted; the three principal realms of human life (the home, the workplace, and leisure activity), as well as ...
doaj   +2 more sources

East-West Center and the Pacific [PDF]

open access: yes, 1985
For more about the East-West Center, see http://www.eastwestcenter.org/
East-West Center
core  

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