Results 31 to 40 of about 19,870 (265)

Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐small‐cell lung cancer (NSCLC) demonstrated a favourable benefit–risk profile. This study evaluated population pharmacokinetics (PopPK) and exposure–response (ER) relationships of durvalumab in patients ...
Xiaoying Zhao   +12 more
wiley   +1 more source

First record of the blacktip reef shark Carcharhinus melanopterus (Carcharhiniformes: Carcharhinidae) from the Tropical Eastern Pacific

open access: yesRevista de Biología Tropical, 2012
The blacktip reef shark Carcharhinus melanopterus, is one of the most common Indo-Pacific reef sharks. On April 29, 2012, a juvenile male blacktip reef shark measuring 89 cm total length (TL), was incidentally caught during a research expedition in ...
Andrés López-Garro   +3 more
doaj   +2 more sources

Platinum Group Element Traces of CAMP Volcanism Associated With Low‐Latitude Environmental and Biological Disruptions

open access: yesGeophysical Monograph Series, Page 263-304., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Jessica H. Whiteside   +3 more
wiley  

+3 more sources

Dissolved iron distribution in the tropical and sub tropical South Eastern Pacific [PDF]

open access: yesBiogeosciences, 2007
Abstract. Dissolved iron (DFe) distributions (<0.2 μm) were determined in the upper water column (0–400 m) of the south eastern tropical and subtropical Pacific, in October–November 2004. Data were collected along a transect extending from the Marquesas Islands to the Chilean coast with most of the stations located in the south Pacific gyre.
Blain, S., Bonnet, Sébastien, Guieu, C.
openaire   +6 more sources

A review of the historic and present ecological role of aquatic and shoreline wood, from forest to deep sea

open access: yesBiological Reviews, EarlyView.
ABSTRACT The ecology of forests, their losses, and terrestrial wood decomposition dynamics have been intensively studied and reviewed. In the aquatic realm, reviews have concentrated on large wood (LW) in rivers and the transition from freshwater to marine environments in the Pacific Northwest of North America. However, a comprehensive global synthesis
Jon Dickson   +9 more
wiley   +1 more source

Impact of Trans-Atlantic-Pacific Ocean Dipole–like pattern on summer precipitation variability over West Africa

open access: yesAtmospheric and Oceanic Science Letters, 2018
Recent findings indicate that rainfall variability over West Africa is characterized by more positive anomalies in the last four decades. The authors demonstrate that the recent interannual rainfall variability is linked to an air–sea phenomenon that ...
Zhao-Hui LIN, DIKE Victor Nnamdi
doaj   +1 more source

Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani [PDF]

open access: yesMarine Drugs, 2018
Despite a large occurrence, especially over the Pacific Ocean, the chemical diversity of marine invertebrates belonging to the order Zoantharia is largely underexplored. For the two species of the genus Antipathozoanthus no chemical study has been reported so far.
Paul Guillen   +6 more
openaire   +4 more sources

The impacts of biological invasions

open access: yesBiological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock   +42 more
wiley   +1 more source

On the Westward Shift and Strengthening of the Atmosphere‐To‐Ocean Bjerknes Feedback in the Tropical Pacific Since 2000

open access: yesGeophysical Research Letters
The behavior of the El Niño–Southern Oscillation (ENSO) has undergone significant changes since the year 2000. Meanwhile, a notable westward shift and strengthening in the atmosphere‐to‐ocean Bjerknes feedback were observed.
Zongrong Li   +4 more
doaj   +1 more source

Trends in marine species distribution models: a review of methodological advances and future challenges

open access: yesEcography, EarlyView.
Correlative species distribution models (SDMs) are quantitative tools in biogeography and macroecology. Building upon the ecological niche concept, they correlate environmental covariates to species presence to model habitat suitability and predict species distributions.
Moritz Klaassen   +3 more
wiley   +1 more source

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